isl1 ISL LIM homeobox 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: isl1provided by Xenbase
Official Full Name: ISL LIM homeobox 1provided by Xenbase
Primary source: Xenbase:XB-GENE-481336
See related: AllianceGenome:Xenbase:XB-GENE-481336
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: isl2; isl-1; Xisl-1; islet1; islet-1; Xislet-1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and metal ion binding activity. Predicted to act upstream of or within neuron fate specification and positive regulation of transcription by RNA polymerase II. Predicted to be located in membrane and nucleus. Is expressed in cardiovascular system; ectoderm; endoderm; nervous system; and visual system. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (193413805..193415261, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (180496769..180498225, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We provide a detailed and exhaustive description of forebrain regions, nuclei, and neuronal populations which express the LIM-homeodomain transcription factor Islet1 during Xenopus development
Title: Islet1 as a marker of subdivisions and cell types in the developing forebrain of Xenopus.

Submit: New GeneRIF Correction

General gene information

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Markers

D10Bir8 (e-PCR), detects polymorphism
- UniSTS:141487

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neuron fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin gene enhancer protein ISL-1

Names: ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL2 transcription factor, LIM/homeodomain, (islet-2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001016720.2 → NP_001016720.1 insulin gene enhancer protein ISL-1

Status: PROVISIONAL

Source sequence(s)

CR760079

UniProtKB/TrEMBL

A0A8J0PIC3

Conserved Domains (1) summary

cd09366
Location:17 → 71

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family