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xpnpep3 X-prolyl aminopeptidase 3, mitochondrial [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 549269, updated on 4-Nov-2024

Summary

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Official Symbol
xpnpep3provided by Xenbase
Official Full Name
X-prolyl aminopeptidase 3, mitochondrialprovided by Xenbase
Primary source
Xenbase:XB-GENE-5770341
See related
Ensembl:ENSXETG00000022973 AllianceGenome:Xenbase:XB-GENE-5770341
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable manganese ion binding activity and metalloaminopeptidase activity. Human ortholog(s) of this gene implicated in nephronophthisis-like nephropathy 1. Orthologous to human XPNPEP3 (X-prolyl aminopeptidase 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See xpnpep3 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (115887724..115901723)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (105889353..105903343)

Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene fragile histidine triad Neighboring gene ST13, Hsp70 interacting protein Neighboring gene E1A binding protein p300 Neighboring gene ring-box 1, E3 ubiquitin protein ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
xaa-Pro aminopeptidase 3
NP_001016515.1
XP_017948540.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001016515.2 → NP_001016515.1  xaa-Pro aminopeptidase 3

    See identical proteins and their annotated locations for NP_001016515.1

    Status: PROVISIONAL

    Source sequence(s)
    CR926224
    UniProtKB/TrEMBL
    A0A6I8RMR3, F7EQV4, Q28CS3
    Related
    ENSXETP00000083509.2, ENSXETT00000091447.2
    Conserved Domains (3) summary
    PRK10879
    Location:60 → 490
    PRK10879; proline aminopeptidase P II; Provisional
    smart01011
    Location:60 → 199
    AMP_N; Aminopeptidase P, N-terminal domain
    cd01087
    Location:246 → 485
    Prolidase; Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on ...

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    115887724..115901723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018093051.2 → XP_017948540.2  xaa-Pro aminopeptidase 3 isoform X1

    UniProtKB/TrEMBL
    A0A6I8RMR3, A0A803KJV2
    Related
    ENSXETP00000049688.4, ENSXETT00000049688.4
    Conserved Domains (2) summary
    smart01011
    Location:48 → 187
    AMP_N; Aminopeptidase P, N-terminal domain
    cd01087
    Location:234 → 473
    Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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