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ercc6 excision repair cross-complementation group 6 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 548810, updated on 4-Nov-2024

Summary

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Official Symbol
ercc6provided by Xenbase
Official Full Name
excision repair cross-complementation group 6provided by Xenbase
Primary source
Xenbase:XB-GENE-1007918
See related
Ensembl:ENSXETG00000026664 AllianceGenome:Xenbase:XB-GENE-1007918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
csb; ckn2; cofs; armd5; cofs1; rad26
Summary
Predicted to enable several functions, including ATP binding activity; ATP-dependent chromatin remodeler activity; and helicase activity. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ercc6 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 7 NC_030683.2 (62529471..62566522, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 7 NC_030683.1 (37455975..37463380, complement)

Chromosome 7 - NC_030683.2Genomic Context describing neighboring genes Neighboring gene dorsal root ganglia homeobox Neighboring gene antidorsalizing morphogenetic protein 2 Neighboring gene uncharacterized LOC101734687 Neighboring gene C-X-C motif chemokine ligand 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
excision repair cross-complementation group 6
Names
excision repair cross-complementing rodent repair deficiency, complementation group 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374666.1 → NP_001361595.1  excision repair cross-complementation group 6

    Status: VALIDATED

    Source sequence(s)
    AAMC03026987, AAMC03026988, AAMC03026989
    UniProtKB/TrEMBL
    A0A8J0QHE8
    Related
    ENSXETP00000091632.2, ENSXETT00000095376.2
    Conserved Domains (4) summary
    COG0553
    Location:430 → 966
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    TIGR02169
    Location:97 → 190
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd18000
    Location:467 → 654
    DEXHc_ERCC6; DEXH-box helicase domain of ERCC6
    cl00613
    Location:4 → 175
    ATP-synt_D; ATP synthase subunit D

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030683.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    62529471..62566522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031905066.1 → XP_031760926.1  excision repair cross-complementation group 6 isoform X1

    UniProtKB/TrEMBL
    A0A6I8S1G0
    Conserved Domains (4) summary
    COG0553
    Location:430 → 966
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    COG1196
    Location:41 → 196
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd18000
    Location:467 → 654
    DEXHc_ERCC6; DEXH-box helicase domain of ERCC6
    cd21397
    Location:61 → 137
    cc_ERCC-6_N; coiled-coil domain located near the N-terminus of human Excision Repair Cross Complementing 6 (ERCC-6) and related proteins

  2. XM_031905067.1 → XP_031760927.1  excision repair cross-complementation group 6 isoform X2

    UniProtKB/TrEMBL
    A0A8J1JSP0
    Conserved Domains (1) summary
    COG0553
    Location:225 → 761
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001016056.2: Suppressed sequence

    Description
    NM_001016056.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  2. NR_164661.1: Suppressed sequence

    Description
    NR_164661.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

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