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TEX10 testis expressed 10 [ Homo sapiens (human) ]

Gene ID: 54881, updated on 2-Nov-2024

Summary

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Official Symbol
TEX10provided by HGNC
Official Full Name
testis expressed 10provided by HGNC
Primary source
HGNC:HGNC:25988
See related
Ensembl:ENSG00000136891 MIM:616717; AllianceGenome:HGNC:25988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ipi1; bA208F1.2
Summary
Located in mitochondrion and nucleoplasm. Part of MLL1 complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 16.8), placenta (RPKM 10.7) and 25 other tissues See more
Orthologs
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Genomic context

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See TEX10 in Genome Data Viewer
Location:
9q31.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (100302084..100352942, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (112473720..112524578, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (103064366..103115224, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene inversin Neighboring gene Sharpr-MPRA regulatory region 13033 Neighboring gene Nanog homeobox pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28722 Neighboring gene uncharacterized LOC124902235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:103046218-103046718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:103046719-103047219 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:103103415-103103914 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:103114917-103115551 Neighboring gene uncharacterized LOC105376177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28723 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:103131616-103131808 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:103155294-103155664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20137 Neighboring gene MSANTD3-TMEFF1 readthrough Neighboring gene Myb/SANT DNA binding domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway. Xiang X, et al. Oncol Rep, 2019 Dec. PMID 31638260, Free PMC Article
  2. Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma. Yoshitake H, et al. Cancer Biomark, 2012-2013. PMID 23481573
  3. Tex10 is upregulated and promotes cancer stem cell properties and chemoresistance in hepatocellular carcinoma. Xiang X, et al. Cell Cycle, 2018. PMID 30045663, Free PMC Article
  4. LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer. Liang JH, et al. Bioengineered, 2022 Feb. PMID 35156514, Free PMC Article
  5. TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6. Luo S, et al. J Immunol Res, 2021. PMID 34966825, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer.
    Title: LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer.
  2. TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6.
    Title: TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6.
  3. LncRNA GATA3AS1miR30b5pTex10 axis modulates tumorigenesis in pancreatic cancer.
    Title: LncRNA GATA3‑AS1‑miR‑30b‑5p‑Tex10 axis modulates tumorigenesis in pancreatic cancer.
  4. Elevated expression of TEX10 was positively associated with malignancy and with epithelialmesenchymal transition (EMT)associated mesenchymal markers in human esophageal squamous cell carcinoma (ESCC) specimens. Study revealed that TEX10 promotes stem celllike features and plays an essential role in regulating EMT via the activation of Wnt/betacatenin signaling in ESCC.
    Title: Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway.
  5. Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC]
    Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
  6. Tex10 plays a potent carcinogenic role in hepatocellular carcinoma tumorigenesis by maintaining cancer stem cell properties through activation of the STAT3 signaling pathway and promoting chemo-resistance.
    Title: Tex10 is upregulated and promotes cancer stem cell properties and chemoresistance in hepatocellular carcinoma.
  7. Tex10 is a core component of the pluripotency network.
    Title: Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming.
  8. Data suggest that TEX101 is a cancer-related protein and may be useful as a marker for prognosis/diagnosis of and neck squamous cell carcinomas (HNSCC).
    Title: Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma.
  9. These data define the PELP1-TEX10-WDR18 complex as a regulator of ribosome biogenesis and suggests that its SUMO-controlled distribution coordinates the rate of ribosome formation.
    Title: The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20287, FLJ31157, FLJ34350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
testis-expressed protein 10
Names
testis expressed gene 10
testis-expressed sequence 10 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161584.2 → NP_001155056.1  testis-expressed protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001155056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at an alternate AUG and result in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AA436854, AK302619
    Consensus CDS
    CCDS55330.1
    UniProtKB/TrEMBL
    B4DQR0
    Related
    ENSP00000444555.1, ENST00000535814.5
    Conserved Domains (1) summary
    pfam12333
    Location:135 → 238
    Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

  2. NM_017746.4 → NP_060216.2  testis-expressed protein 10 isoform 1

    See identical proteins and their annotated locations for NP_060216.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA436854, AB060968, BC030652, BP336313
    Consensus CDS
    CCDS6748.1
    UniProtKB/Swiss-Prot
    B4DYV2, Q5T722, Q5T723, Q8NCN8, Q8TDY0, Q9NXF1
    UniProtKB/TrEMBL
    B4DQR0
    Related
    ENSP00000364037.4, ENST00000374902.9
    Conserved Domains (1) summary
    pfam12333
    Location:132 → 235
    Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    100302084..100352942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518798.3 → XP_011517100.1  testis-expressed protein 10 isoform X1

    UniProtKB/TrEMBL
    B4DQR0
    Conserved Domains (1) summary
    pfam12333
    Location:132 → 235
    Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

  2. XM_047423523.1 → XP_047279479.1  testis-expressed protein 10 isoform X2

  3. XM_047423524.1 → XP_047279480.1  testis-expressed protein 10 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    112473720..112524578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363149.1 → XP_054219124.1  testis-expressed protein 10 isoform X1

  2. XM_054363150.1 → XP_054219125.1  testis-expressed protein 10 isoform X2

  3. XM_054363151.1 → XP_054219126.1  testis-expressed protein 10 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NXF1.2 GenPept UniProtKB/Swiss-Prot:Q9NXF1

Gene LinkOut

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