slc30a5 solute carrier family 30 (zinc transporter), member 5 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: slc30a5provided by Xenbase
Official Full Name: solute carrier family 30 (zinc transporter), member 5provided by Xenbase
Primary source: Xenbase:XB-GENE-962722
See related: Ensembl:ENSXETG00000000472 AllianceGenome:Xenbase:XB-GENE-962722
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: znt5; ztl1; zntl1
Summary: Predicted to enable zinc:proton antiporter activity. Predicted to be involved in intracellular zinc ion homeostasis and zinc ion import into Golgi lumen. Predicted to act upstream of with a positive effect on GPI anchor biosynthetic process. Predicted to act upstream of or within zinc ion import into organelle. Predicted to be located in Golgi apparatus; cytoplasmic vesicle membrane; and endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and cytoplasmic vesicle. Orthologous to human SLC30A5 (solute carrier family 30 member 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (186436279..186452726, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (173663234..173679596, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect GPI anchor biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular zinc ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import into Golgi lumen	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zinc ion import into Golgi lumen	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within zinc ion import into organelle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within zinc ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ER to Golgi transport vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in ER to Golgi transport vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi cis cisterna membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in secretory granule membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proton-coupled zinc antiporter SLC30A5; zinc transporter 5

Names: solute carrier family 30 member 5; znT-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015911.1 → NP_001015911.1 proton-coupled zinc antiporter SLC30A5

See identical proteins and their annotated locations for NP_001015911.1

Status: PROVISIONAL

Source sequence(s)

CR926426

UniProtKB/Swiss-Prot

Q08D30, Q28CE7

UniProtKB/TrEMBL

F7END2

Related

ENSXETP00000001010.4, ENSXETT00000001010.4

Conserved Domains (2) summary

COG1230
Location:411 → 741

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:424 → 661

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

186436279..186452726 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031899676.1 → XP_031755536.1 zinc transporter 5 isoform X1

UniProtKB/TrEMBL

A0A6I8PV98, A0A6I8QXD6

Related

ENSXETP00000063192.3, ENSXETT00000064263.3

Conserved Domains (1) summary

COG1230
Location:411 → 726

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]