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asb1 ankyrin repeat and SOCS box containing 1 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 548381, updated on 4-Nov-2024

Summary

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Official Symbol
asb1provided by Xenbase
Official Full Name
ankyrin repeat and SOCS box containing 1provided by Xenbase
Primary source
Xenbase:XB-GENE-5793268
See related
Ensembl:ENSXETG00000004879 AllianceGenome:Xenbase:XB-GENE-5793268
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB1 (ankyrin repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See asb1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
6
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 9 NC_030685.2 (60743980..60753558)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 9 NC_030685.1 (55634423..55643643)

Chromosome 9 - NC_030685.2Genomic Context describing neighboring genes Neighboring gene TRAF3 interacting protein 1 Neighboring gene pancreas transcription factor 1 subunit alpha-like Neighboring gene anterior gradient 1 Neighboring gene histone deacetylase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030685.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    60743980..60753558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004917881.4 → XP_004917938.1  ankyrin repeat and SOCS box protein 1 isoform X1

    UniProtKB/TrEMBL
    F6TQ54, Q5FVV9
    Related
    ENSXETP00000010588.5, ENSXETT00000010588.5
    Conserved Domains (4) summary
    cd00204
    Location:31 → 156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03720
    Location:298 → 339
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    pfam12796
    Location:33 → 130
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:71 → 100
    ANK; ANK repeat [structural motif]

  2. XM_031893512.1 → XP_031749372.1  ankyrin repeat and SOCS box protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1IUU4, Q5FVV9
    Related
    ENSXETP00000101963.1, ENSXETT00000115406.1
    Conserved Domains (5) summary
    PHA02875
    Location:72 → 263
    PHA02875; ankyrin repeat protein; Provisional
    cd03720
    Location:285 → 326
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    sd00045
    Location:71 → 100
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:74 → 164
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:25 → 100
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
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