micu2 mitochondrial calcium uptake 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: micu2provided by ZNC
Official Full Name: mitochondrial calcium uptake 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3374
See related: Ensembl:ENSDARG00000009939 AllianceGenome:ZFIN:ZDB-GENE-030131-3374
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: efha1; fc37d04; wu:fc37d04; zgc:113196; si:ch211-222c22.8
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to act upstream of or within mitochondrial calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of uniplex complex. Orthologous to human MICU2 (mitochondrial calcium uptake 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (36599122..36609700)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (35998958..36009547)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb70a11.y1 (e-PCR)
- UniSTS:191013

fc37d04.x1 (e-PCR)
- UniSTS:188061

fk68e12.x1 (e-PCR)
- UniSTS:201418

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcium uptake protein 2, mitochondrial

Names: EF-hand domain family, member A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017539.2 → NP_001017539.2 calcium uptake protein 2, mitochondrial

Status: VALIDATED

Source sequence(s)

AI584211, DT062305, EB906767, EH439002, EH448877, EH464933, EH465902

UniProtKB/TrEMBL

A0A8M1N571, Q1LYC5

Related

ENSDARP00000088447.3, ENSDART00000097677.5

Conserved Domains (3) summary

pfam13499
Location:171 → 242

EF-hand_7; EF-hand domain pair

pfam13833
Location:331 → 380

EF-hand_8; EF-hand domain pair

cl08302
Location:171 → 242

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

36599122..36609700

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165311.5 → XP_005165368.1 calcium uptake protein 2, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8M2BCK2, Q1LYC6

Related

ENSDARP00000119805.1, ENSDART00000138147.2

Conserved Domains (3) summary

pfam13499
Location:171 → 224

EF-hand_7; EF-hand domain pair

pfam13833
Location:313 → 362

EF-hand_8; EF-hand domain pair

cl08302
Location:171 → 224

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...