Tfip11 tuftelin interacting protein 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tfip11provided by MGI
Official Full Name: tuftelin interacting protein 11provided by MGI
Primary source: MGI:MGI:1930075
See related: Ensembl:ENSMUSG00000029345 AllianceGenome:MGI:1930075
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Srr1; TIP33; Tip39; 2810002G02Rik
Summary: Predicted to enable nucleic acid binding activity. Involved in spliceosomal complex disassembly. Located in extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; ganglia; nose; and retina. Orthologous to human TFIP11 (tuftelin interacting protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 25.3), thymus adult (RPKM 19.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 54.69 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (112474235..112485939)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (112326369..112338073)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a member of oxygen-sensitive genes and implicated in the adaptive mechanisms regulating mesenchymal stem cell function
Title: Biphasic influence of hypoxia on tuftelin expression in mouse mesenchymal C3H10T1/2 stem cells.
These data help define the mechanism of nuclear/nuclear speckle localization of the splicing factor TFIP11, with implications for it's function.
Title: Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW046167 (e-PCR)
- UniSTS:179237

AF097181 (e-PCR)
- UniSTS:163368

Tfip11 (e-PCR), detects polymorphism
- UniSTS:479292

MARC_7037-7038:992008225:1 (e-PCR)
- UniSTS:231297

MARC_7037-7038:996687489:1 (e-PCR)
- UniSTS:231297

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in extracellular matrix organization	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal complex disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spliceosomal complex disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spliceosomal complex disassembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of U2-type post-mRNA release spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type post-mRNA release spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISA Inferred from Sequence Alignment more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISA Inferred from Sequence Alignment more info	PubMed
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tuftelin-interacting protein 11

Names: STIP-1; septin and tuftelin-interacting protein 1; tuftelin-interacting protein 33; tuftelin-interacting protein 39; tuftelin-interacting protein, 39 kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018783.4 → NP_061253.2 tuftelin-interacting protein 11

See identical proteins and their annotated locations for NP_061253.2

Status: PROVISIONAL

Source sequence(s)

AC123848

Consensus CDS

CCDS19539.1

UniProtKB/Swiss-Prot

Q8VD06, Q9ERA6

UniProtKB/TrEMBL

Q3TTV6, Q3UGE9

Related

ENSMUSP00000031288.8, ENSMUST00000031288.14

Conserved Domains (3) summary

pfam01585
Location:150 → 194

G-patch; G-patch domain

pfam07842
Location:398 → 667

GCFC; GC-rich sequence DNA-binding factor-like protein

pfam12457
Location:21 → 105

TIP_N; Tuftelin interacting protein N terminal