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KIF1A kinesin family member 1A [ Homo sapiens (human) ]

Gene ID: 547, updated on 12-Nov-2024

Summary

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Official Symbol
KIF1Aprovided by HGNC
Official Full Name
kinesin family member 1Aprovided by HGNC
Primary source
HGNC:HGNC:888
See related
Ensembl:ENSG00000130294 MIM:601255; AllianceGenome:HGNC:888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATSV; MRD9; HSN2C; SPG30; SPG30A; SPG30B; UNC104; C2orf20; NESCAVS
Summary
The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Expression
Biased expression in brain (RPKM 88.6), adrenal (RPKM 8.2) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See KIF1A in Genome Data Viewer
Location:
2q37.3
Exon count:
55
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240713767..240821403, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241210501..241320366, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241653184..241760820, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC285191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241637868-241638651 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:241646918-241647077 Neighboring gene aquaporin 12A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241651331-241652138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241673162-241673662 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:241678910-241680109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241736458-241736958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241736959-241737459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241737588-241738429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241751150-241751760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241756052-241756691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241760048-241760622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241771685-241772681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241778610-241779110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241807760-241808260 Neighboring gene alanine--glyoxylate aminotransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241834201-241834836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241836109-241836744 Neighboring gene mab-21 like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A. Lessard DV, et al. J Biol Chem, 2019 Apr 19. PMID 30770469, Free PMC Article
  2. Phenotypic expansion in KIF1A-related dominant disorders: A description of novel variants and review of published cases. Montenegro-Garreaud X, et al. Hum Mutat, 2020 Dec. PMID 32935419, Free PMC Article
  3. Autosomal recessive spastic paraplegia (SPG30) with mild ataxia and sensory neuropathy maps to chromosome 2q37.3. Klebe S, et al. Brain, 2006 Jun. PMID 16434418
  4. Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders. Nicita F, et al. J Med Genet, 2021 Jul. PMID 32737135
  5. High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations. Kikkawa M, et al. EMBO J, 2006 Sep 20. PMID 16946706, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF1A promotes neuroendocrine differentiation in prostate cancer by regulating the OGT-mediated O-GlcNAcylation.
    Title: KIF1A promotes neuroendocrine differentiation in prostate cancer by regulating the OGT-mediated O-GlcNAcylation.
  2. Heterogeneity of comprehensive clinical phenotype and longitudinal adaptive function and correlation with computational predictions of severity of missense genotypes in KIF1A-associated neurological disorder.
    Title: Heterogeneity of comprehensive clinical phenotype and longitudinal adaptive function and correlation with computational predictions of severity of missense genotypes in KIF1A-associated neurological disorder.
  3. KIF1A novel frameshift variant p.(Ser887Profs*64) exhibits clinical heterogeneity in a Pakistani family with hereditary sensory and autonomic neuropathy type IIC.
    Title: KIF1A novel frameshift variant p.(Ser887Profs*64) exhibits clinical heterogeneity in a Pakistani family with hereditary sensory and autonomic neuropathy type IIC.
  4. Autosomal dominant neurodevelopmental disorders associated with KIF1A gene variants in 6 pediatric patients.
    Title: Autosomal dominant neurodevelopmental disorders associated with KIF1A gene variants in 6 pediatric patients.
  5. [KIF1A gene-associated neurological disease: the correlation between genotype and phenotype].
    Title: [KIF1A gene-associated neurological disease: the correlation between genotype and phenotype].
  6. Identification of an in-frame homozygous KIF1A variant causing a mild SPG30 phenotype in a Korean family.
    Title: Identification of an in-frame homozygous KIF1A variant causing a mild SPG30 phenotype in a Korean family.
  7. [Analysis of KIF1A gene variant in a Chinese pedigree affected with Spastic paraplegia type 30].
    Title: [Analysis of KIF1A gene variant in a Chinese pedigree affected with Spastic paraplegia type 30].
  8. Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder.
    Title: Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder.
  9. Investigating KIF1A mutations in a Taiwanese cohort with hereditary spastic paraplegia.
    Title: Investigating KIF1A mutations in a Taiwanese cohort with hereditary spastic paraplegia.
  10. De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors.
    Title: De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hereditary spastic paraplegia 30
MedGen: C5235139 OMIM: 610357 GeneReviews: Not available
not available
Intellectual disability, autosomal dominant 9
MedGen: C5393830 OMIM: 614255 GeneReviews: Not available
not available
Neuropathy, hereditary sensory and autonomic, type 2A
MedGen: C2752089 OMIM: 201300 GeneReviews: Hereditary Sensory and Autonomic Neuropathy Type II
not available
Neuropathy, hereditary sensory, type 2C
MedGen: C3280168 OMIM: 614213 GeneReviews: Hereditary Sensory and Autonomic Neuropathy Type II
not available

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2013-08-08)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2013-08-08)

ClinGen Genome Curation Page

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
capsid gag The ability of exogenously expressed FEZ1 binding to kinesin-1 to promote early HIV-1 infection, leading to the movement of HIV-1 CA core to the nucleus PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30229, MGC133285, MGC133286, DKFZp686I2094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in anterograde neuronal dense core vesicle transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dense core granule cytoskeletal transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde neuronal dense core vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde neuronal dense core vesicle transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal dense core vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal dense core vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF1A
Names
axonal transporter of synaptic vesicles
kinesin, heavy chain, member 1A, homolog of mouse
microtubule-based motor KIF1A
unc-104- and KIF1A-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029724.1 RefSeqGene

    Range
    4900..111444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_367

mRNA and Protein(s)

  1. NM_001244008.2 → NP_001230937.1  kinesin-like protein KIF1A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    Consensus CDS
    CCDS58757.1
    UniProtKB/TrEMBL
    A0A6Q8PFR5
    Related
    ENSP00000438388.1, ENST00000498729.9
    Conserved Domains (8) summary
    smart00129
    Location:5 → 361
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:501 → 605
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1672 → 1774
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00169
    Location:1677 → 1770
    PH; PH domain
    pfam12423
    Location:814 → 861
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1297 → 1397
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 524
    Kinesin_assoc; Kinesin-associated

  2. NM_001320705.2 → NP_001307634.1  kinesin-like protein KIF1A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB210029, AB290172, AC011298, AW246876, BC111780
    Consensus CDS
    CCDS92991.1
    UniProtKB/TrEMBL
    A0A3B3IU40, X5D7J0
    Related
    ENSP00000498196.1, ENST00000648364.1
    Conserved Domains (8) summary
    smart00129
    Location:5 → 361
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:501 → 605
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1580 → 1682
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00169
    Location:1585 → 1678
    PH; PH domain
    pfam12423
    Location:814 → 860
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1205 → 1305
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 524
    Kinesin_assoc; Kinesin-associated

  3. NM_001330289.2 → NP_001317218.1  kinesin-like protein KIF1A isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784, AK054791, AW246876
    Consensus CDS
    CCDS92992.1
    UniProtKB/TrEMBL
    A0A3B3IT28, H7C3Y8
    Related
    ENSP00000497586.1, ENST00000648680.1
    Conserved Domains (8) summary
    smart00129
    Location:5 → 361
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:501 → 605
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1589 → 1691
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00169
    Location:1594 → 1687
    PH; PH domain
    pfam12423
    Location:814 → 860
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1205 → 1314
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 524
    Kinesin_assoc; Kinesin-associated

  4. NM_001330290.2 → NP_001317219.1  kinesin-like protein KIF1A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784, AK054791, AW246876
    Consensus CDS
    CCDS92993.1
    UniProtKB/TrEMBL
    A0A3B3ITE5, X5D7J0
    Related
    ENSP00000497678.1, ENST00000649306.1

  5. NM_001379631.1 → NP_001366560.1  kinesin-like protein KIF1A isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    A0A6Q8PFR5

  6. NM_001379632.1 → NP_001366561.1  kinesin-like protein KIF1A isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    A0AAQ5BID6
    Conserved Domains (6) summary
    cd00060
    Location:492 → 596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1664 → 1766
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805 → 852
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1233 → 1389
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated

  7. NM_001379633.1 → NP_001366562.1  kinesin-like protein KIF1A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    Consensus CDS
    CCDS92990.1
    UniProtKB/TrEMBL
    A0A3B3ITW6, A0AAQ5BID6
    Related
    ENSP00000497293.1, ENST00000648129.1

  8. NM_001379634.1 → NP_001366563.1  kinesin-like protein KIF1A isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    H7C3Y8

  9. NM_001379635.1 → NP_001366564.1  kinesin-like protein KIF1A isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    A0A3B3ITK3, H7C3Y8
    Conserved Domains (6) summary
    cd00060
    Location:526 → 630
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1613 → 1715
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:839 → 885
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1183 → 1338
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 549
    Kinesin_assoc; Kinesin-associated

  10. NM_001379636.1 → NP_001366565.1  kinesin-like protein KIF1A isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    Consensus CDS
    CCDS92989.1
    UniProtKB/TrEMBL
    A0A3B3ITF7, X5D7J0
    Related
    ENSP00000497739.1, ENST00000647885.1
    Conserved Domains (7) summary
    cd01233
    Location:1609 → 1711
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00769
    Location:624 → 678
    ERM; Ezrin/radixin/moesin family
    pfam12423
    Location:805 → 852
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1149 → 1331
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated
    cd22726
    Location:491 → 605
    FHA_KIF1A; forkhead associated (FHA) domain found in kinesin-like protein KIF1A

  11. NM_001379637.1 → NP_001366566.1  kinesin-like protein KIF1A isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    X5D7J0
    Conserved Domains (7) summary
    cd01233
    Location:1596 → 1698
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00769
    Location:649 → 703
    ERM; Ezrin/radixin/moesin family
    pfam12423
    Location:830 → 877
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1174 → 1318
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 540
    Kinesin_assoc; Kinesin-associated
    cd22726
    Location:516 → 630
    FHA_KIF1A; forkhead associated (FHA) domain found in kinesin-like protein KIF1A

  12. NM_001379638.1 → NP_001366567.1  kinesin-like protein KIF1A isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    H7C3Y8
    Conserved Domains (6) summary
    cd00060
    Location:501 → 605
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1588 → 1690
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:814 → 860
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1158 → 1313
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 524
    Kinesin_assoc; Kinesin-associated

  13. NM_001379639.1 → NP_001366568.1  kinesin-like protein KIF1A isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    Consensus CDS
    CCDS92987.1
    UniProtKB/TrEMBL
    A0A3F2YNW9, X5D7J0
    Related
    ENSP00000322791.8, ENST00000320389.12
    Conserved Domains (6) summary
    cd00060
    Location:492 → 596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1579 → 1681
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805 → 851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1149 → 1304
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated

  14. NM_001379640.1 → NP_001366569.1  kinesin-like protein KIF1A isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    X5D7J0
    Conserved Domains (6) summary
    cd00060
    Location:492 → 596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1570 → 1672
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805 → 851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1148 → 1295
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated

  15. NM_001379641.1 → NP_001366570.1  kinesin-like protein KIF1A isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    X5D7J0
    Conserved Domains (6) summary
    cd00060
    Location:492 → 596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1571 → 1661
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805 → 851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1149 → 1296
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated

  16. NM_001379642.1 → NP_001366571.1  kinesin-like protein KIF1A isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    A0AAQ5BID6
    Conserved Domains (6) summary
    cd00060
    Location:492 → 596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1672 → 1774
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805 → 852
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1241 → 1397
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated

  17. NM_001379645.1 → NP_001366574.1  kinesin-like protein KIF1A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    Consensus CDS
    CCDS92990.1
    UniProtKB/TrEMBL
    A0A3B3ITW6, A0AAQ5BID6
    Related
    ENSP00000498082.1, ENST00000650130.1

  18. NM_001379646.1 → NP_001366575.1  kinesin-like protein KIF1A isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    A0A3B3ITK3, H7C3Y8
    Related
    ENSP00000497935.2, ENST00000648047.2
    Conserved Domains (6) summary
    cd00060
    Location:526 → 630
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1613 → 1715
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:839 → 885
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1183 → 1338
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 549
    Kinesin_assoc; Kinesin-associated

  19. NM_001379648.1 → NP_001366577.1  kinesin-like protein KIF1A isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    UniProtKB/TrEMBL
    H7C3Y8
    Conserved Domains (3) summary
    cd00060
    Location:517 → 621
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1605 → 1707
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

  20. NM_001379649.1 → NP_001366578.1  kinesin-like protein KIF1A isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    Consensus CDS
    CCDS92988.1
    UniProtKB/TrEMBL
    A0A3B3IUA1, X5D7J0
    Related
    ENSP00000498099.1, ENST00000647731.1
    Conserved Domains (6) summary
    cd00060
    Location:492 → 596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1580 → 1682
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805 → 851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1149 → 1305
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated

  21. NM_001379650.1 → NP_001366579.1  kinesin-like protein KIF1A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    Consensus CDS
    CCDS46561.1
    UniProtKB/Swiss-Prot
    B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
    UniProtKB/TrEMBL
    X5D7J0
    Related
    ENSP00000497824.1, ENST00000650053.1
    Conserved Domains (6) summary
    cd00060
    Location:492 → 596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1571 → 1673
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805 → 851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1149 → 1296
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated

  22. NM_001379651.1 → NP_001366580.1  kinesin-like protein KIF1A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    Consensus CDS
    CCDS46561.1
    UniProtKB/Swiss-Prot
    B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
    UniProtKB/TrEMBL
    X5D7J0
    Conserved Domains (6) summary
    cd00060
    Location:492 → 596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1571 → 1673
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805 → 851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1149 → 1296
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated

  23. NM_001379653.1 → NP_001366582.1  kinesin-like protein KIF1A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    Consensus CDS
    CCDS46561.1
    UniProtKB/Swiss-Prot
    B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
    UniProtKB/TrEMBL
    X5D7J0
    Conserved Domains (6) summary
    cd00060
    Location:492 → 596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1571 → 1673
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805 → 851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1149 → 1296
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated

  24. NM_004321.8 → NP_004312.2  kinesin-like protein KIF1A isoform 2

    See identical proteins and their annotated locations for NP_004312.2

    Status: REVIEWED

    Source sequence(s)
    AC011298, AC112784
    Consensus CDS
    CCDS46561.1
    UniProtKB/Swiss-Prot
    B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
    UniProtKB/TrEMBL
    X5D7J0
    Related
    ENSP00000497030.1, ENST00000649096.1
    Conserved Domains (6) summary
    cd00060
    Location:492 → 596
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:1571 → 1673
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:4 → 361
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam12423
    Location:805 → 851
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1149 → 1296
    DUF3694; Kinesin protein
    pfam16183
    Location:358 → 515
    Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    240713767..240821403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444819.1 → XP_047300775.1  kinesin-like protein KIF1A isoform X1

    UniProtKB/TrEMBL
    C9JBH1

  2. XM_047444821.1 → XP_047300777.1  kinesin-like protein KIF1A isoform X3

  3. XM_047444820.1 → XP_047300776.1  kinesin-like protein KIF1A isoform X2

    Related
    ENSP00000384231.5, ENST00000404283.9

  4. XM_047444818.1 → XP_047300774.1  kinesin-like protein KIF1A isoform X1

    UniProtKB/TrEMBL
    C9JBH1
    Related
    ENSP00000398686.2, ENST00000448728.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    241210501..241320366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342651.1 → XP_054198626.1  kinesin-like protein KIF1A isoform X1

  2. XM_054342653.1 → XP_054198628.1  kinesin-like protein KIF1A isoform X3

  3. XM_054342652.1 → XP_054198627.1  kinesin-like protein KIF1A isoform X2

  4. XM_054342650.1 → XP_054198625.1  kinesin-like protein KIF1A isoform X1

  5. XM_054342654.1 → XP_054198629.1  kinesin-like protein KIF1A isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12756.2 GenPept UniProtKB/Swiss-Prot:Q12756

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