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Hgfac hepatocyte growth factor activator [ Mus musculus (house mouse) ]

Gene ID: 54426, updated on 2-Nov-2024

Summary

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Official Symbol
Hgfacprovided by MGI
Official Full Name
hepatocyte growth factor activatorprovided by MGI
Primary source
MGI:MGI:1859281
See related
Ensembl:ENSMUSG00000029102 AllianceGenome:MGI:1859281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HGFA
Summary
This gene encodes a serine protease enzyme that proteolytically activates hepatocyte growth factor (HGF) and plays a vital role in the regulation of HGF activity in the regeneration and repair of various tissues. The encoded protein is an inactive zymogen that is proteolytically activated to generate a heterodimeric enzyme consisting of a short chain and a long chain linked by a disulfide bridge. Mice lacking the encoded protein display an impairment in mucosal regeneration after injury. [provided by RefSeq, Jul 2015]
Expression
Biased expression in colon adult (RPKM 227.5), liver adult (RPKM 215.9) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Hgfac in Genome Data Viewer
Location:
5 B2; 5 17.99 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35198853..35205805)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35041509..35048461)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Myb/SANT-like DNA-binding domain containing 1 Neighboring gene regulator of G-protein signaling 12 Neighboring gene STARR-seq mESC enhancer starr_12848 Neighboring gene STARR-seq mESC enhancer starr_12849 Neighboring gene microRNA 3097 Neighboring gene docking protein 7 Neighboring gene STARR-seq mESC enhancer starr_12851 Neighboring gene STARR-positive B cell enhancer ABC_E3569 Neighboring gene low density lipoprotein receptor-related protein associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract. Itoh H, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760594
  2. Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels. Yamagata Y, et al. Am J Physiol Gastrointest Liver Physiol, 2012 Dec 1. PMID 23064758, Free PMC Article
  3. Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice. Itoh H, et al. Gastroenterology, 2004 Nov. PMID 15521012
  4. Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells. Ohki T, et al. Biochem Biophys Res Commun, 2012 Aug 31. PMID 22877752
  5. Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption. Banna FKE, et al. Sci Rep, 2022 Jun 4. PMID 35661789, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
    Title: HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
  2. HNF1alpha might regulate beta-cell mass or function at least partly by modulating Hgfac expression.
    Title: Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells.
  3. HGFA is required for repair of injured intestinal mucosa but is not essential for normal development during embryogenesis or after birth.
    Title: Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in rough endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hepatocyte growth factor activator
Names
HGF activator
NP_062320.2
XP_006504094.1
XP_006504095.1
XP_006504096.1
XP_030110566.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019447.3 → NP_062320.2  hepatocyte growth factor activator preproprotein

    See identical proteins and their annotated locations for NP_062320.2

    Status: REVIEWED

    Source sequence(s)
    AK149522, AK165433, BY195777
    Consensus CDS
    CCDS19223.1
    UniProtKB/Swiss-Prot
    Q9JKV4, Q9R098
    UniProtKB/TrEMBL
    Q545J3, Q8VCS4
    Related
    ENSMUSP00000030985.7, ENSMUST00000030985.10
    Conserved Domains (6) summary
    smart00059
    Location:99 → 145
    FN2; Fibronectin type 2 domain
    smart00020
    Location:405 → 639
    Tryp_SPc; Trypsin-like serine protease
    cd00054
    Location:159 → 194
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:197 → 237
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00190
    Location:406 → 641
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:283 → 364
    Kringle; Kringle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    35198853..35205805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504031.3 → XP_006504094.1  hepatocyte growth factor activator isoform X1

    UniProtKB/TrEMBL
    Q8VCS4
    Conserved Domains (5) summary
    smart00059
    Location:99 → 145
    FN2; Fibronectin type 2 domain
    cd00054
    Location:159 → 194
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:197 → 237
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00190
    Location:406 → 646
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:283 → 364
    Kringle; Kringle domain

  2. XM_006504032.3 → XP_006504095.1  hepatocyte growth factor activator isoform X2

    UniProtKB/TrEMBL
    Q8VCS4
    Conserved Domains (4) summary
    smart00059
    Location:99 → 145
    FN2; Fibronectin type 2 domain
    cd00054
    Location:159 → 194
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:362 → 602
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:239 → 320
    Kringle; Kringle domain

  3. XM_030254706.1 → XP_030110566.1  hepatocyte growth factor activator isoform X3

    UniProtKB/TrEMBL
    Q8VCS4
    Conserved Domains (4) summary
    smart00059
    Location:99 → 145
    FN2; Fibronectin type 2 domain
    cd00054
    Location:159 → 194
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:362 → 597
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:239 → 320
    Kringle; Kringle domain

  4. XM_006504033.1 → XP_006504096.1  hepatocyte growth factor activator isoform X4

    Conserved Domains (4) summary
    smart00059
    Location:99 → 145
    FN2; Fibronectin type 2 domain
    cd00054
    Location:159 → 194
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:197 → 237
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00051
    Location:283 → 364
    Kringle; Kringle domain

RNA

  1. XR_376817.1 RNA Sequence

  2. XR_003955676.1 RNA Sequence

  3. XR_376819.4 RNA Sequence

  4. XR_376818.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R098.1 GenPept UniProtKB/Swiss-Prot:Q9R098

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