ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ippkprovided by ZNC
Official Full Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050327-41
See related: Ensembl:ENSDARG00000003446 AllianceGenome:ZFIN:ZDB-GENE-050327-41
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ipk1; ipk1l; zgc:110769; si:dkey-42i9.3
Summary: Enables inositol pentakisphosphate 2-kinase activity. Acts upstream of or within epithelial cilium movement involved in determination of left/right asymmetry and melanosome transport. Located in centrosome and ciliary basal body. Is expressed in axial mesoderm; blastodisc; germ ring; margin; and tail bud. Orthologous to human IPPK (inositol-pentakisphosphate 2-kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (10516332..10539167, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (10486650..10509485, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ipk1 plays a previously uncharacterized role in ciliary function
Title: A role for the inositol kinase Ipk1 in ciliary beating and length maintenance.
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ipk1), which generates inositol hexakisphosphate, is critical for normal LR axis determination in zebrafish
Title: Inositol polyphosphates regulate zebrafish left-right asymmetry.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of left/right symmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol-pentakisphosphate 2-kinase

Names: inositol 1,3,4,5,6-pentakisphosphate 2-kinase, like; ins(1,3,4,5,6)P5 2-kinase; insP5 2-kinase

NP_001014346.1

EC 2.7.1.158

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.