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Rps28 ribosomal protein S28 [ Mus musculus (house mouse) ]

Gene ID: 54127, updated on 2-Nov-2024

Summary

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Official Symbol
Rps28provided by MGI
Official Full Name
ribosomal protein S28provided by MGI
Primary source
MGI:MGI:1859516
See related
Ensembl:ENSMUSG00000067288 AllianceGenome:MGI:1859516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; maturation of SSU-rRNA; and ribosomal small subunit assembly. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; hemolymphoid system; and vitelline vein. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 15 with mandibulofacial dysostosis. Orthologous to human RPS28 (ribosomal protein S28). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 320.6), CNS E11.5 (RPKM 303.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rps28 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34042010..34043536, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33823036..33824562, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene angiopoietin-like 4 Neighboring gene predicted gene, 53997 Neighboring gene STARR-seq mESC enhancer starr_42411 Neighboring gene STARR-positive B cell enhancer ABC_E956 Neighboring gene KN motif and ankyrin repeat domains 3 Neighboring gene STARR-positive B cell enhancer ABC_E2482 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7 Neighboring gene CD320 antigen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of a gene trap reporter construct in a subset of cells in embryonic sites of hematopoiesis: evidence for alternative rRNA production in hematopoietic cells. Wagner DS, et al. Biochem Biophys Res Commun, 1998 Sep 29. PMID 9784405
  2. The complete nucleotide sequence of mouse 28S rRNA gene. Implications for the process of size increase of the large subunit rRNA in higher eukaryotes. Hassouna N, et al. Nucleic Acids Res, 1984 Apr 25. PMID 6328426, Free PMC Article
  3. Drp1 regulates transcription of ribosomal protein genes in embryonic hearts. Zhao Q, et al. J Cell Sci, 2022 Feb 15. PMID 35099001, Free PMC Article
  4. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104
  5. A male germ-cell-specific ribosome controls male fertility. Li H, et al. Nature, 2022 Dec. PMID 36517592

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasmic side of rough endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small ribosomal subunit protein eS28
Names
40S ribosomal protein S28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355384.1 → NP_001342313.1  small ribosomal subunit protein eS28

    Status: VALIDATED

    Source sequence(s)
    CT030732
    Consensus CDS
    CCDS37571.1
    UniProtKB/Swiss-Prot
    P62858, Q5BKQ7
    UniProtKB/TrEMBL
    G3UYV7, Q059I1
    Related
    ENSMUSP00000133357.2, ENSMUST00000173844.8
    Conserved Domains (1) summary
    cd04457
    Location:10 → 69
    S1_S28E; S28E, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. S28E protein is a component of the 30S ribosomal subunit. S28E is highly conserved among archaea and eukaryotes. S28E may control ...

  2. NM_016844.3 → NP_058540.1  small ribosomal subunit protein eS28

    See identical proteins and their annotated locations for NP_058540.1

    Status: VALIDATED

    Source sequence(s)
    CT030732
    Consensus CDS
    CCDS37571.1
    UniProtKB/Swiss-Prot
    P62858, Q5BKQ7
    UniProtKB/TrEMBL
    G3UYV7, Q059I1
    Related
    ENSMUSP00000110013.5, ENSMUST00000087342.13
    Conserved Domains (1) summary
    cd04457
    Location:10 → 69
    S1_S28E; S28E, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. S28E protein is a component of the 30S ribosomal subunit. S28E is highly conserved among archaea and eukaryotes. S28E may control ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34042010..34043536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62858.1 GenPept UniProtKB/Swiss-Prot:P62858

Gene LinkOut

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