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MPZ myelin protein zero [ Bos taurus (domestic cattle) ]

Gene ID: 539462, updated on 4-Oct-2024

Summary

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Official Symbol
MPZprovided by VGNC
Official Full Name
myelin protein zeroprovided by VGNC
Primary source
VGNC:VGNC:31591
See related
BGD:BT21654; Ensembl:ENSBTAG00000033835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Summary
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]
Orthologs
human mouse all
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Genomic context

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See MPZ in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (8211217..8216082)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 126 Neighboring gene succinate dehydrogenase complex subunit C Neighboring gene Purkinje cell protein 4 like 1 Neighboring gene nuclear receptor subfamily 1 group I member 3 Neighboring gene translocase of outer mitochondrial membrane 40 like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complete amino acid sequence of PO protein in bovine peripheral nerve myelin. Sakamoto Y, et al. J Biol Chem, 1987 Mar 25. PMID 2435734
  2. Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ. Yamaguchi Y, et al. Neurochem Res, 2018 Jan. PMID 29081003
  3. L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough. Yamaguchi Y, et al. J Biol Chem, 2012 May 18. PMID 22457349, Free PMC Article
  4. Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Beier H, et al. Nucleic Acids Res, 2001 Dec 1. PMID 11726686, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in myelination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
myelin protein P0
Names
MPP
myelin peripheral protein
myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079507.2 → NP_001072975.1  myelin protein P0 isoform MPZ precursor

    See identical proteins and their annotated locations for NP_001072975.1

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (MPZ).
    Source sequence(s)
    BC122659, EE369960
    UniProtKB/Swiss-Prot
    P10522, Q05B76
    Related
    ENSBTAP00000045141.2, ENSBTAT00000048021.4
    Conserved Domains (2) summary
    pfam10570
    Location:184 → 248
    Myelin-PO_C; Myelin-PO cytoplasmic C-term p65 binding region
    cd05879
    Location:30 → 146
    IgV_P0; Immunoglobulin (Ig)-like domain of protein zero (P0)

  2. NM_001316359.1 → NP_001303288.1  myelin protein P0 isoform L-MPZ precursor

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (L-MPZ). As the UAG stop codon has been reported to specify several alternative amino acids (glutamine, tyrosine and leucine), its location in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    BC122659, EE369960
    UniProtKB/Swiss-Prot
    P10522
    Conserved Domains (2) summary
    cd05879
    Location:31 → 146
    Ig_P0; Immunoglobulin (Ig)-like domain of Protein zero (P0)
    pfam10570
    Location:184 → 248
    Myelin-PO_C; Myelin-PO cytoplasmic C-term p65 binding region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    8211217..8216082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10522.2 GenPept UniProtKB/Swiss-Prot:P10522

Gene LinkOut

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