CWC15 CWC15 spliceosome associated protein homolog [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CWC15provided by VGNC
Official Full Name: CWC15 spliceosome associated protein homologprovided by VGNC
Primary source: VGNC:VGNC:54863
See related: BGD:BT25729; Ensembl:ENSBTAG00000007913
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	15	NC_037342.1 (15447275..15456213)

Chromosome 15 - NC_037342.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

By combining SNP analysis of whole-genome sequences aligned to the JH1 interval and subsequent SNP validation a nonsense mutation in CWC15 was identified as the likely causative mutation underlying the fertility phenotype
Title: Identification of a nonsense mutation in CWC15 associated with decreased reproductive efficiency in Jersey cattle.

Submit: New GeneRIF Correction

General gene information

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Markers

HSPC148 (e-PCR)
- UniSTS:278542

WI-11443 (e-PCR)
- UniSTS:22934

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA cis splicing, via spliceosome	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: spliceosome-associated protein CWC15 homolog

Names: CWC15 homolog; protein CWC15 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001046399.2 → NP_001039864.1 spliceosome-associated protein CWC15 homolog

See identical proteins and their annotated locations for NP_001039864.1

Status: PROVISIONAL

Source sequence(s)

BC105398

UniProtKB/Swiss-Prot

Q2KJD3

Related

ENSBTAP00000010403.3, ENSBTAT00000010403.4

Conserved Domains (1) summary

pfam04889
Location:1 → 230

Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

Range

15447275..15456213

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005215765.5 → XP_005215822.1 spliceosome-associated protein CWC15 homolog isoform X1

See identical proteins and their annotated locations for XP_005215822.1

UniProtKB/Swiss-Prot

Q2KJD3

Conserved Domains (1) summary

pfam04889
Location:1 → 230

Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein
XM_005215764.3 → XP_005215821.1 spliceosome-associated protein CWC15 homolog isoform X1

See identical proteins and their annotated locations for XP_005215821.1

UniProtKB/Swiss-Prot

Q2KJD3

Conserved Domains (1) summary

pfam04889
Location:1 → 230

Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein