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MFN2 mitofusin 2 [ Bos taurus (domestic cattle) ]

Gene ID: 534574, updated on 10-Oct-2024

Summary

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Official Symbol
MFN2provided by VGNC
Official Full Name
mitofusin 2provided by VGNC
Primary source
VGNC:VGNC:31428
See related
Ensembl:ENSBTAG00000005314
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See MFN2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (41683878..41711316, complement)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 1B Neighboring gene TNF receptor superfamily member 8 Neighboring gene migration and invasion inhibitory protein Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Neighboring gene KIAA2013 ortholog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Low abundance of mitofusin 2 in dairy cows with moderate fatty liver is associated with alterations in hepatic lipid metabolism. Dong J, et al. J Dairy Sci, 2019 Aug. PMID 31178189
  2. An unusual splice defect in the mitofusin 2 gene (MFN2) is associated with degenerative axonopathy in Tyrolean Grey cattle. Drögemüller C, et al. PLoS One, 2011 Apr 15. PMID 21526202, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dairy cows with moderate fatty liver displayed hepatic lipid accumulation and lower abundance of hepatic MFN2, peroxisome proliferator-activated receptor-alpha (PPARalpha), and carnitine palmitoyltransferase 1A (CPT1A).
    Title: Low abundance of mitofusin 2 in dairy cows with moderate fatty liver is associated with alterations in hepatic lipid metabolism.
  2. A highly unusual splicing defect, where an exonic single base exchange leads to the retention of the preceding intron, was identified in MFN2.
    Title: An unusual splice defect in the mitofusin 2 gene (MFN2) is associated with degenerative axonopathy in Tyrolean Grey cattle.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitochondrion localization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitofusin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190269.1 → NP_001177198.1  mitofusin-2

    See identical proteins and their annotated locations for NP_001177198.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer variant. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    FN868563
    UniProtKB/TrEMBL
    A0AAF6DM48, D7GLD1
    Related
    ENSBTAP00000070841.1, ENSBTAT00000080672.2
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:595 → 754
    Fzo_mitofusin; fzo-like conserved region

  2. NM_001190270.1 → NP_001177199.1  mitofusin-2

    See identical proteins and their annotated locations for NP_001177199.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    FN868564
    UniProtKB/TrEMBL
    A0AAF6DM48, D7GLD1
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:595 → 754
    Fzo_mitofusin; fzo-like conserved region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    41683878..41711316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024976327.2 → XP_024832095.1  mitofusin-2 isoform X1

    UniProtKB/TrEMBL
    A0AAF6DM48, D7GLD0, E1BKT8
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:595 → 754
    Fzo_mitofusin; fzo-like conserved region

  2. XM_024976324.2 → XP_024832092.1  mitofusin-2 isoform X1

    UniProtKB/TrEMBL
    A0AAF6DM48, D7GLD0, E1BKT8
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:595 → 754
    Fzo_mitofusin; fzo-like conserved region

  3. XM_059875435.1 → XP_059731418.1  mitofusin-2 isoform X1

    UniProtKB/TrEMBL
    D7GLD0, E1BKT8

  4. XM_024976328.2 → XP_024832096.1  mitofusin-2 isoform X1

    UniProtKB/TrEMBL
    A0AAF6DM48, D7GLD0, E1BKT8
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:595 → 754
    Fzo_mitofusin; fzo-like conserved region

  5. XM_024976326.2 → XP_024832094.1  mitofusin-2 isoform X1

    UniProtKB/TrEMBL
    A0AAF6DM48, D7GLD0, E1BKT8
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:595 → 754
    Fzo_mitofusin; fzo-like conserved region

  6. XM_024976330.2 → XP_024832098.1  mitofusin-2 isoform X1

    UniProtKB/TrEMBL
    A0AAF6DM48, D7GLD0, E1BKT8
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:595 → 754
    Fzo_mitofusin; fzo-like conserved region

  7. XM_024976329.2 → XP_024832097.1  mitofusin-2 isoform X1

    UniProtKB/TrEMBL
    A0AAF6DM48, D7GLD0, E1BKT8
    Conserved Domains (2) summary
    cd09912
    Location:97 → 349
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:595 → 754
    Fzo_mitofusin; fzo-like conserved region
Nucleotide Protein Strain
Heading Accession and Version

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