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ATP4A ATPase H+/K+ transporting subunit alpha [ Bos taurus (domestic cattle) ]

Gene ID: 521163, updated on 4-Oct-2024

Summary

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Official Symbol
ATP4Aprovided by VGNC
Official Full Name
ATPase H+/K+ transporting subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:58589
See related
BGD:BT18606; Ensembl:ENSBTAG00000008777
Gene type
protein coding
RefSeq status
INFERRED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See ATP4A in Genome Data Viewer
Location:
chromosome: 18
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (46209080..46222026, complement)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene transmembrane protein 147 Neighboring gene uncharacterized LOC786928 Neighboring gene PMIS2 transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables P-type potassium:proton transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables P-type sodium:potassium-exchanging transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
potassium-transporting ATPase alpha chain 1
Names
ATPase H+/K+ transporting alpha subunit
ATPase, H+/K+ exchanging, alpha polypeptide
NP_001137561.1
XP_059732728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144089.1 → NP_001137561.1  potassium-transporting ATPase alpha chain 1

    Status: INFERRED

    Source sequence(s)
    NKLS02000018
    UniProtKB/TrEMBL
    F1MXW4
    Related
    ENSBTAP00000011569.6, ENSBTAT00000011569.6
    Conserved Domains (7) summary
    smart00831
    Location:50 → 124
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:616 → 742
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:37 → 1034
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:145 → 375
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:809 → 1018
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam09040
    Location:2 → 42
    H-K_ATPase_N; Gastric H+/K+-ATPase, N terminal domain
    pfam13246
    Location:437 → 531
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    46209080..46222026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059876745.1 → XP_059732728.1  potassium-transporting ATPase alpha chain 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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