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PDE1C phosphodiesterase 1C [ Homo sapiens (human) ]

Gene ID: 5137, updated on 3-Nov-2024

Summary

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Official Symbol
PDE1Cprovided by HGNC
Official Full Name
phosphodiesterase 1Cprovided by HGNC
Primary source
HGNC:HGNC:8776
See related
Ensembl:ENSG00000154678 MIM:602987; AllianceGenome:HGNC:8776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hcam3; DFNA74; hCam-3; cam-PDE 1C
Summary
This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
Expression
Biased expression in heart (RPKM 9.1), brain (RPKM 4.0) and 12 other tissues See more
Orthologs
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Genomic context

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See PDE1C in Genome Data Viewer
Location:
7p14.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (31616777..32428224, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (31754475..32567499, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (31790793..32467836, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs297 Neighboring gene NANOG hESC enhancer GRCh37_chr7:31411185-31411804 Neighboring gene uncharacterized LOC105375224 Neighboring gene neuronal differentiation 6 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:31505615-31506326 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:31506327-31507037 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:31517206-31518405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25823 Neighboring gene ITPR interacting domain containing 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:31690801-31691359 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:31749869-31750495 Neighboring gene protein phosphatase 1 regulatory subunit 17 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:31807284-31808218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25824 Neighboring gene NANOG hESC enhancer GRCh37_chr7:31865149-31865650 Neighboring gene Sharpr-MPRA regulatory region 14950 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:31977838-31979037 Neighboring gene sorting nexin 2 pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:32202217-32203416 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:32244753-32245952 Neighboring gene MPRA-validated peak6468 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:32467257-32468070 Neighboring gene NANOG hESC enhancer GRCh37_chr7:32486745-32487256 Neighboring gene phosphoribosyl pyrophosphate synthetase 2 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:32503825-32504417 Neighboring gene solute carrier family 25 member 5 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Subcellular localization and regulation of type-1C and type-5 phosphodiesterases. Dolci S, et al. Biochem Biophys Res Commun, 2006 Mar 17. PMID 16455054
  2. Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation. Rybalkin SD, et al. Circ Res, 2002 Feb 8. PMID 11834707
  3. Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes. Brzezinska P, et al. J Biol Chem, 2021 Jan-Jun. PMID 33789162, Free PMC Article
  4. Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro. Rowther FB, et al. Mol Carcinog, 2016 Mar. PMID 25620587
  5. Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm. Zhang C, et al. Proc Natl Acad Sci U S A, 2021 Aug 3. PMID 34312235, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm.
    Title: Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm.
  2. Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes.
    Title: Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes.
  3. By combining population-specific mutation arrays, targeted deafness genes panel, whole exome sequencing (WES), we identified PDE1C (Phosphodiesterase 1C) c.958G>T (p.A320S) as the disease-associated variant. Structural modeling insights into p.A320S strongly suggest that the sequence alteration will likely affect the substrate-binding pocket of PDE1C.
    Title: A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss.
  4. PDE1C is a proliferation-associated gene in glioblastoma multiforme cells in vitro.
    Title: Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro.
  5. PDE1C is an important regulator of SMC proliferation, migration, and neointimal hyperplasia, in part through modulating endosome/lysosome-dependent PDGFRbeta protein degradation via low-density lipoprotein receptor-related protein-1.
    Title: Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
  9. PDE1C1 is expressed at high levels in human cardiac myocytes with an intracellular distribution distinct from that of PDE3A
    Title: Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.
  10. PDE1C levels decreased in all conditions that inhibited proliferation
    Title: Subcellular localization and regulation of type-1C and type-5 phosphodiesterases.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hearing loss, autosomal dominant 74
MedGen: C4748334 OMIM: 618140 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study link novel loci to endometriosis.
EBI GWAS Catalog
Genome-wide association study of antiphospholipid antibodies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Names
3',5'-cyclic-AMP phosphodiesterase
3',5'-cyclic-GMP phosphodiesterase
Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A)
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
phosphodiesterase 1C, calmodulin-dependent 70kDa
NP_001177985.1
NP_001177986.1
NP_001177987.2
NP_001177988.1
NP_001308984.1
NP_001308985.1
NP_001308986.1
NP_001308987.1
NP_001308988.1
NP_005011.1
XP_016867753.1
XP_016867754.1
XP_016867755.1
XP_016867756.1
XP_047276396.1
XP_047276397.1
XP_047276398.1
XP_047276399.1
XP_047276400.1
XP_047276401.1
XP_047276402.1
XP_054214305.1
XP_054214306.1
XP_054214307.1
XP_054214308.1
XP_054214309.1
XP_054214310.1
XP_054214311.1
XP_054214312.1
XP_054214313.1
XP_054214314.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051183.2 RefSeqGene

    Range
    362817..682045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001191056.3 → NP_001177985.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 1

    See identical proteins and their annotated locations for NP_001177985.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' and 3' UTR and has multiple coding region differences, compared to variant 3. These differences result in an isoform (1) with distinct N- and C-termini, compared to isoform 3. Variants 1 and 4 encode the same protein. Isoform 1 is also known as HCam-3B.
    Source sequence(s)
    AC004931, AC006377, AK056170, AK125029, BM668260, U40371
    Consensus CDS
    CCDS5437.1
    UniProtKB/TrEMBL
    Q8TAE4
    Related
    ENSP00000379485.2, ENST00000396182.6
    Conserved Domains (2) summary
    pfam00233
    Location:227 → 445
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86 → 142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  2. NM_001191057.4 → NP_001177986.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2

    See identical proteins and their annotated locations for NP_001177986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences result in an isoform (2) with a distinct N-terminus, compared to isoform 3. Variants 2 and 5 encode the same protein. Isoform 2 is also known as HCam-3A.
    Source sequence(s)
    AC006377, AC007093, AI168057, AI301181, AK056170, CB135276, HY125708
    Consensus CDS
    CCDS55099.1
    UniProtKB/Swiss-Prot
    B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
    UniProtKB/TrEMBL
    B3KSS6
    Related
    ENSP00000379494.1, ENST00000396191.6
    Conserved Domains (2) summary
    pfam00233
    Location:227 → 455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86 → 142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  3. NM_001191058.4 → NP_001177987.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3). Variants 3 and 10 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC006377, AC007093, AC018637, AI168057, AI301181, AK056170, AK091734, CB135276, HY125708
    Consensus CDS
    CCDS55100.1
    UniProtKB/TrEMBL
    A0A0A0MS69, B3KSS6
    Related
    ENSP00000379496.1, ENST00000396193.5
    Conserved Domains (2) summary
    pfam00233
    Location:287 → 515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:142 → 202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  4. NM_001191059.4 → NP_001177988.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2

    See identical proteins and their annotated locations for NP_001177988.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences result in an isoform (2) with a distinct N-terminus, compared to isoform 3. Variants 2 and 5 encode the same protein. Isoform 2 is also known as HCam-3A.
    Source sequence(s)
    AC006377, AC007093, AI168057, AI301181, AK056170, CB135276, DA023468, HY125708
    Consensus CDS
    CCDS55099.1
    UniProtKB/Swiss-Prot
    B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
    UniProtKB/TrEMBL
    B3KSS6
    Related
    ENSP00000318105.7, ENST00000321453.12
    Conserved Domains (2) summary
    pfam00233
    Location:227 → 455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86 → 142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  5. NM_001322055.2 → NP_001308984.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004931, AC006377, AC007093, AI168057, AI301181, AK056170, CB135276, DA174241, DA231237, HY125708
    Consensus CDS
    CCDS55099.1
    UniProtKB/Swiss-Prot
    B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
    UniProtKB/TrEMBL
    B3KSS6
    Conserved Domains (2) summary
    pfam00233
    Location:227 → 455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86 → 142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  6. NM_001322056.2 → NP_001308985.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004931, AC006377
    Consensus CDS
    CCDS5437.1
    UniProtKB/TrEMBL
    Q8TAE4
    Conserved Domains (2) summary
    pfam00233
    Location:227 → 445
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86 → 142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  7. NM_001322057.2 → NP_001308986.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004931, AC006377
    Consensus CDS
    CCDS5437.1
    UniProtKB/TrEMBL
    Q8TAE4
    Conserved Domains (2) summary
    pfam00233
    Location:227 → 445
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86 → 142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  8. NM_001322058.2 → NP_001308987.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC005589, AC006377, AC018637, KF458425
    UniProtKB/TrEMBL
    Q75MP2
    Conserved Domains (2) summary
    pfam00233
    Location:287 → 505
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146 → 202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  9. NM_001322059.2 → NP_001308988.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Variants 3 and 10 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC005589, AC006377, AC018637, KF458425
    UniProtKB/Swiss-Prot
    Q14123
    Conserved Domains (2) summary
    pfam00233
    Location:362 → 590
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:221 → 277
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  10. NM_005020.5 → NP_005011.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform 1

    See identical proteins and their annotated locations for NP_005011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTR and has multiple coding region differences, compared to variant 3. These differences result in an isoform (1) with distinct N- and C-termini, compared to isoform 3. Variants 1 and 4 encode the same protein. Isoform 1 is also known as HCam-3B.
    Source sequence(s)
    AC004931, AC006377
    Consensus CDS
    CCDS5437.1
    UniProtKB/TrEMBL
    Q8TAE4
    Related
    ENSP00000379487.3, ENST00000396184.7
    Conserved Domains (2) summary
    pfam00233
    Location:227 → 445
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86 → 142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    31616777..32428224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420443.1 → XP_047276399.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

  2. XM_047420442.1 → XP_047276398.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

  3. XM_047420441.1 → XP_047276397.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

  4. XM_017012264.1 → XP_016867753.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

    UniProtKB/TrEMBL
    B3KSS6

  5. XM_017012265.1 → XP_016867754.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

    UniProtKB/TrEMBL
    B3KSS6

  6. XM_047420440.1 → XP_047276396.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

    UniProtKB/Swiss-Prot
    B3KPC6, E9PE92, Q14123, Q14124, Q8NB10

  7. XM_017012267.2 → XP_016867756.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

    UniProtKB/Swiss-Prot
    B3KPC6, E9PE92, Q14123, Q14124, Q8NB10
    UniProtKB/TrEMBL
    B3KSS6
    Conserved Domains (2) summary
    pfam00233
    Location:227 → 455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86 → 142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  8. XM_047420445.1 → XP_047276401.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X7

  9. XM_017012266.2 → XP_016867755.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3

    UniProtKB/TrEMBL
    Q75MP2

  10. XM_047420444.1 → XP_047276400.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6

  11. XM_047420446.1 → XP_047276402.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X8

RNA

  1. XR_001744802.1 RNA Sequence

  2. XR_001744803.1 RNA Sequence

  3. XR_007060044.1 RNA Sequence

  4. XR_007060042.1 RNA Sequence

  5. XR_007060043.1 RNA Sequence

  6. XR_007060041.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    31754475..32567499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358337.1 → XP_054214312.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

  2. XM_054358336.1 → XP_054214311.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

  3. XM_054358335.1 → XP_054214310.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

  4. XM_054358330.1 → XP_054214305.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

  5. XM_054358331.1 → XP_054214306.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

  6. XM_054358333.1 → XP_054214308.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

    UniProtKB/Swiss-Prot
    B3KPC6, E9PE92, Q14123, Q14124, Q8NB10

  7. XM_054358334.1 → XP_054214309.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

    UniProtKB/Swiss-Prot
    B3KPC6, E9PE92, Q14123, Q14124, Q8NB10

  8. XM_054358332.1 → XP_054214307.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3

  9. XM_054358338.1 → XP_054214313.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6

  10. XM_054358339.1 → XP_054214314.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X8

RNA

  1. XR_008487624.1 RNA Sequence

  2. XR_008487625.1 RNA Sequence

  3. XR_008487629.1 RNA Sequence

  4. XR_008487627.1 RNA Sequence

  5. XR_008487628.1 RNA Sequence

  6. XR_008487626.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14123.1 GenPept UniProtKB/Swiss-Prot:Q14123

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