CLCN7 chloride voltage-gated channel 7 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CLCN7provided by VGNC
Official Full Name: chloride voltage-gated channel 7provided by VGNC
Primary source: VGNC:VGNC:27401
See related: BGD:BT30438; Ensembl:ENSBTAG00000015889
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CLC7; CLC-7
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	25	NC_037352.1 (1138163..1158734, complement)

Chromosome 25 - NC_037352.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

accelerated ClC-7/Ostm1 gating per se is deleterious, highlighting a physiological importance of the slow voltage-activation of ClC-7/Ostm1 in lysosomal function and bone resorption
Title: A missense mutation accelerating the gating of the lysosomal Cl-/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_26178-26179:1030651018:3 (e-PCR)
- UniSTS:268972

MARC_5469-5470:996690416:1 (e-PCR)
- UniSTS:269523

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables voltage-gated chloride channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: H(+)/Cl(-) exchange transporter 7

Names: chloride channel 7 alpha subunit; chloride channel protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025331.1 → NP_001020502.1 H(+)/Cl(-) exchange transporter 7

See identical proteins and their annotated locations for NP_001020502.1

Status: PROVISIONAL

Source sequence(s)

DQ073465

UniProtKB/Swiss-Prot

Q4PKH3

UniProtKB/TrEMBL

A6QQR2

Related

ENSBTAP00000021122.6, ENSBTAT00000021122.7

Conserved Domains (4) summary

COG0517
Location:742 → 799

CBS; CBS domain [Signal transduction mechanisms]

cd03685
Location:99 → 624

ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...

cd04591
Location:640 → 794

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

pfam00654
Location:190 → 599

Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

Range

1138163..1158734 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_059881286.1 → XP_059737269.1 H(+)/Cl(-) exchange transporter 7 isoform X1
XM_010819084.4 → XP_010817386.1 H(+)/Cl(-) exchange transporter 7 isoform X1

See identical proteins and their annotated locations for XP_010817386.1

UniProtKB/TrEMBL

A0A3Q1M3Q5

Conserved Domains (4) summary

COG0517
Location:666 → 723

CBS; CBS domain [Signal transduction mechanisms]

cd03685
Location:23 → 548

ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...

cd04591
Location:564 → 718

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

pfam00654
Location:114 → 523

Voltage_CLC; Voltage gated chloride channel