U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZBTB7A zinc finger and BTB domain containing 7A [ Homo sapiens (human) ]

Gene ID: 51341, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ZBTB7Aprovided by HGNC
Official Full Name
zinc finger and BTB domain containing 7Aprovided by HGNC
Primary source
HGNC:HGNC:18078
See related
Ensembl:ENSG00000178951 MIM:605878; AllianceGenome:HGNC:18078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRF; FBI1; FBI-1; TIP21; ZBTB7; MNDLFH; ZNF857A; pokemon
Summary
Enables several functions, including SMAD binding activity; nuclear androgen receptor binding activity; and transcription corepressor binding activity. Involved in several processes, including erythrocyte maturation; negative regulation of signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon (RPKM 8.0), stomach (RPKM 5.5) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZBTB7A in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4043303..4066899, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4026415..4050025, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4043301..4066897, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3984027-3984878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3987713-3988214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3988215-3988714 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3998837-3999482 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:4006760-4007651 and GRCh37_chr19:4007652-4008542 Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4043682-4044414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4062546-4063053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9880 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:4068686-4068844 Neighboring gene MPRA-validated peak3265 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4089732-4090508 Neighboring gene mitogen-activated protein kinase kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13758 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:4116105-4116291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9882 Neighboring gene Sharpr-MPRA regulatory region 2607 Neighboring gene Sharpr-MPRA regulatory region 6873 Neighboring gene MPRA-validated peak3267 silencer Neighboring gene cAMP responsive element binding protein 3 like 3 Neighboring gene Sharpr-MPRA regulatory region 11650

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Knockdown of Pokemon protein expression inhibits hepatocellular carcinoma cell proliferation by suppression of AKT activity. Zhu X, et al. Oncol Res, 2013. PMID 23924858
  2. Epidermal growth factor increases LRF/Pokemon expression in human prostate cancer cells. Aggarwal H, et al. Exp Mol Pathol, 2011 Oct. PMID 21640721, Free PMC Article
  3. [Esculin inhibits proliferation of triple negative breast cancer cells by down-regulating FBI-1]. Mo M, et al. Zhonghua Zhong Liu Za Zhi, 2020 Aug 23. PMID 32867453
  4. LRF/ZBTB7A conservation accentuates its potential as a therapeutic target for the hematopoietic disorders. Chondrou V, et al. Gene, 2020 Nov 15. PMID 32755656
  5. FBI-1 promotes cell proliferation and enhances resistance to chemotherapy of hepatocellular carcinoma in vitro and in vivo. Fang F, et al. Cancer, 2012 Jan 1. PMID 21713761

See all (152) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1.
    Title: ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1.
  2. Pokemon inhibits Bim transcription to promote the proliferation, anti-anoikis, invasion, histological grade, and dukes stage of colorectal neoplasms.
    Title: Pokemon inhibits Bim transcription to promote the proliferation, anti-anoikis, invasion, histological grade, and dukes stage of colorectal neoplasms.
  3. Transcriptional repression of lncRNA and miRNA subsets mediated by LRF during erythropoiesis.
    Title: Transcriptional repression of lncRNA and miRNA subsets mediated by LRF during erythropoiesis.
  4. Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia.
    Title: Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia.
  5. Targeting Pokemon is a novel strategy to suppress cancer aggressiveness of non-small cell lung cancer: Identification of Pokemon as ideal target for developing anti-NSCLC drugs.
    Title: Targeting Pokemon is a novel strategy to suppress cancer aggressiveness of non-small cell lung cancer: Identification of Pokemon as ideal target for developing anti-NSCLC drugs.
  6. Post-translational regulation of proto-oncogene ZBTB7A expression by p53 status in cancer cells: HSP90-dependent stabilization vs. p53-KLHL20-ubiquitin proteasomal degradation.
    Title: Post-translational regulation of proto-oncogene ZBTB7A expression by p53 status in cancer cells: HSP90-dependent stabilization vs. p53-KLHL20-ubiquitin proteasomal degradation.
  7. ZBTB7A as a novel vulnerability in neuroendocrine prostate cancer.
    Title: ZBTB7A as a novel vulnerability in neuroendocrine prostate cancer.
  8. ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5.
    Title: ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5.
  9. Microcribriform Adenocarcinoma of Salivary Glands: A Unique Tumor Entity Characterized by an SS18::ZBTB7A Fusion.
    Title: Microcribriform Adenocarcinoma of Salivary Glands: A Unique Tumor Entity Characterized by an SS18::ZBTB7A Fusion.
  10. ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection.
    Title: ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection.
Submit: New GeneRIF Correction See all GeneRIFs (111)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin
MedGen: C5676928 OMIM: 619769 GeneReviews: Not available
not available

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat Binding of FBI-1 to HIV-1 Tat is mediated by the zinc finger (ZF) domain of FBI-1 (amino acids 377-584) and is diminished by point mutations in Tat at amino acids 18, 30, and 31 PubMed
tat FBI-1 is a cellular POZ-domain-containing protein that binds to the HIV-1 LTR and Tat protein and specifically stimulates Tat activity PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC99631, DKFZp547O146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables SMAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone acetyltransferase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear androgen receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear androgen receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via classical nonhomologous end joining ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in erythrocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in erythrocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger and BTB domain-containing protein 7A
Names
HIV-1 1st-binding protein 1
HIV-1 inducer of short transcripts binding protein
POK erythroid myeloid ontogenic factor
POZ and Krueppel erythroid myeloid ontogenic factor
TTF-I-interacting peptide 21
factor binding IST protein 1
factor that binds to inducer of short transcripts protein 1
leukemia/lymphoma-related factor
lymphoma related factor
pokemon 1
zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein
zinc finger protein 857A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317990.2 → NP_001304919.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC016586, BC084568, DB495635
    Consensus CDS
    CCDS12119.1
    UniProtKB/Swiss-Prot
    D6W619, O00456, O95365, Q14D41, Q5XG86
    Related
    ENSP00000471865.1, ENST00000601588.1
    Conserved Domains (3) summary
    sd00017
    Location:412 → 432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9 → 128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:425 → 449
    zf-H2C2_2; Zinc-finger double domain

  2. NM_015898.4 → NP_056982.1  zinc finger and BTB domain-containing protein 7A

    See identical proteins and their annotated locations for NP_056982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC016586, BC084568
    Consensus CDS
    CCDS12119.1
    UniProtKB/Swiss-Prot
    D6W619, O00456, O95365, Q14D41, Q5XG86
    Related
    ENSP00000323670.3, ENST00000322357.9
    Conserved Domains (3) summary
    sd00017
    Location:412 → 432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9 → 128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:425 → 449
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4043303..4066899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259571.5 → XP_005259628.1  zinc finger and BTB domain-containing protein 7A isoform X2

    See identical proteins and their annotated locations for XP_005259628.1

    UniProtKB/Swiss-Prot
    D6W619, O00456, O95365, Q14D41, Q5XG86
    Conserved Domains (3) summary
    sd00017
    Location:412 → 432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9 → 128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:425 → 449
    zf-H2C2_2; Zinc-finger double domain

  2. XM_005259570.6 → XP_005259627.3  zinc finger and BTB domain-containing protein 7A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4026415..4050025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321176.1 → XP_054177151.1  zinc finger and BTB domain-containing protein 7A isoform X2

    UniProtKB/Swiss-Prot
    D6W619, O00456, O95365, Q14D41, Q5XG86

  2. XM_054321175.1 → XP_054177150.1  zinc finger and BTB domain-containing protein 7A isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020224.1: Suppressed sequence

    Description
    NM_020224.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95365.1 GenPept UniProtKB/Swiss-Prot:O95365

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools