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CDK17 cyclin dependent kinase 17 [ Homo sapiens (human) ]

Gene ID: 5128, updated on 14-Nov-2024

Summary

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Official Symbol
CDK17provided by HGNC
Official Full Name
cyclin dependent kinase 17provided by HGNC
Primary source
HGNC:HGNC:8750
See related
Ensembl:ENSG00000059758 MIM:603440; AllianceGenome:HGNC:8750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCTK2; PCTAIRE2
Summary
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in brain (RPKM 21.3), testis (RPKM 15.1) and 24 other tissues See more
Orthologs
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Genomic context

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See CDK17 in Genome Data Viewer
Location:
12q23.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (96278225..96400439, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (96252431..96374639, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96672003..96794217, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6189 Neighboring gene long intergenic non-protein coding RNA 2452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96603880-96604402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6826 Neighboring gene uncharacterized LOC124902991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96628784-96629768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96631810-96632310 Neighboring gene ETS transcription factor ELK3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96709352-96709984 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96709985-96710615 Neighboring gene RNA, U4 small nuclear 24, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6830 Neighboring gene RN7SK pseudogene 11 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:96878154-96878351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6832 Neighboring gene Sharpr-MPRA regulatory region 2123 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:96894427-96895626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4746 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:96915910-96916410 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:96916411-96916911 Neighboring gene cilia and flagella associated protein 54 Neighboring gene MPRA-validated peak1903 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6835 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:97122708-97123302

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology. Chaput D, et al. Oncotarget, 2016 Feb 23. PMID 26885753, Free PMC Article
  2. CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression. Qu B, et al. Carcinogenesis, 2024 Feb 12. PMID 37952105
  3. CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer. Chen R, et al. J Ovarian Res, 2022 Feb 15. PMID 35168653, Free PMC Article
  4. PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. Hirose T, et al. Eur J Biochem, 1997 Oct 15. PMID 9370357
  5. Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain. Hirose T, et al. Eur J Biochem, 2000 Apr. PMID 10727952

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression.
    Title: CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression.
  2. CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.
    Title: CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.
  3. Increased levels of PCTAIRE2 is associated with Alzheimer's disease.
    Title: Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 17
Names
PCTAIRE-motif protein kinase 2
cell division protein kinase 17
protein kinase cdc2-related PCTAIRE-2
serine/threonine-protein kinase PCTAIRE-2
NP_001163935.1
NP_002586.2
XP_016874894.1
XP_016874895.1
XP_016874896.1
XP_054228168.1
XP_054228169.1
XP_054228170.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170464.4 → NP_001163935.1  cyclin-dependent kinase 17 isoform 2

    See identical proteins and their annotated locations for NP_001163935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus but is the same length as isoform 1.
    Source sequence(s)
    AC008149, AC125612, AF086067, AK290011, BC033005, DA530711
    Consensus CDS
    CCDS53819.1
    UniProtKB/TrEMBL
    B4DGP5
    Related
    ENSP00000444459.2, ENST00000543119.6
    Conserved Domains (1) summary
    cd07872
    Location:185 → 493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

  2. NM_002595.5 → NP_002586.2  cyclin-dependent kinase 17 isoform 1

    See identical proteins and their annotated locations for NP_002586.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AF086067, BC033005, DC307775
    Consensus CDS
    CCDS9061.1
    UniProtKB/Swiss-Prot
    A8K1U6, B2RCQ2, Q00537, Q8NEB8
    UniProtKB/TrEMBL
    B4DGP5
    Related
    ENSP00000261211.3, ENST00000261211.8
    Conserved Domains (1) summary
    cd07872
    Location:185 → 493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    96278225..96400439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019407.3 → XP_016874896.1  cyclin-dependent kinase 17 isoform X2

    UniProtKB/TrEMBL
    B4DGP5

  2. XM_017019406.2 → XP_016874895.1  cyclin-dependent kinase 17 isoform X1

    UniProtKB/Swiss-Prot
    A8K1U6, B2RCQ2, Q00537, Q8NEB8
    UniProtKB/TrEMBL
    B4DGP5
    Conserved Domains (1) summary
    cd07872
    Location:185 → 493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

  3. XM_017019405.2 → XP_016874894.1  cyclin-dependent kinase 17 isoform X1

    UniProtKB/Swiss-Prot
    A8K1U6, B2RCQ2, Q00537, Q8NEB8
    UniProtKB/TrEMBL
    B4DGP5
    Conserved Domains (1) summary
    cd07872
    Location:185 → 493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    96252431..96374639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372195.1 → XP_054228170.1  cyclin-dependent kinase 17 isoform X2

  2. XM_054372194.1 → XP_054228169.1  cyclin-dependent kinase 17 isoform X1

    UniProtKB/Swiss-Prot
    A8K1U6, B2RCQ2, Q00537, Q8NEB8

  3. XM_054372193.1 → XP_054228168.1  cyclin-dependent kinase 17 isoform X1

    UniProtKB/Swiss-Prot
    A8K1U6, B2RCQ2, Q00537, Q8NEB8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00537.2 GenPept UniProtKB/Swiss-Prot:Q00537

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