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PHF20 PHD finger protein 20 [ Homo sapiens (human) ]

Gene ID: 51230, updated on 2-Nov-2024

Summary

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Official Symbol
PHF20provided by HGNC
Official Full Name
PHD finger protein 20provided by HGNC
Primary source
HGNC:HGNC:16098
See related
Ensembl:ENSG00000025293 MIM:610335; AllianceGenome:HGNC:16098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NZF; TZP; GLEA2; HCA58; TDRD20A; C20orf104
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nuclear membrane; and nucleoplasm. Part of MLL1 complex and NSL complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 8.8), brain (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

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See PHF20 in Genome Data Viewer
Location:
20q11.22-q11.23
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (35772015..35950370)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (37493003..37671367)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34359937..34538292)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak4202 silencer Neighboring gene uncharacterized LOC124904972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12864 Neighboring gene Sharpr-MPRA regulatory region 2555 Neighboring gene ribosome production factor 2 homolog pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17798 Neighboring gene MPRA-validated peak4203 silencer Neighboring gene COX7B pseudogene 2 Neighboring gene PHF20 intron CAGE-defined high expression enhancer Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 16 Neighboring gene RNA, U4 small nuclear 40, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:34494545-34495045 Neighboring gene RNA, U6 small nuclear 937, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17802 Neighboring gene uncharacterized LOC124904982 Neighboring gene SCAN domain containing 1 Neighboring gene cyclic nucleotide binding domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PHF20 inhibition promotes apoptosis and cisplatin chemosensitivity via the OCT4‑p‑STAT3‑MCL1 signaling pathway in hypopharyngeal squamous cell carcinoma. Liu X, et al. Int J Oncol, 2021 Jul. PMID 33982773, Free PMC Article
  2. Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls. Fischer U, et al. Clin Exp Immunol, 2001 Nov. PMID 11703362, Free PMC Article
  3. Altered expression of tumor suppressor PHF20 in myeloproliferative neoplasms. Lasho TL, et al. Leukemia, 2014 Aug. PMID 24675105
  4. Increased seroreactivity to glioma-expressed antigen 2 in brain tumor patients under radiation. Heisel SM, et al. PLoS One, 2008 May 14. PMID 18478111, Free PMC Article
  5. N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation. Zhang Z, et al. Clin Transl Med, 2022 Aug. PMID 35979628, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation.
    Title: N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation.
  2. PHF20 inhibition promotes apoptosis and cisplatin chemosensitivity via the OCT4pSTAT3MCL1 signaling pathway in hypopharyngeal squamous cell carcinoma.
    Title: PHF20 inhibition promotes apoptosis and cisplatin chemosensitivity via the OCT4‑p‑STAT3‑MCL1 signaling pathway in hypopharyngeal squamous cell carcinoma.
  3. PHF20 interacts with poly(ADP-ribose) polymerase 1 (PARP1) and directly binds to promoter regions of octamer-binding transcription factor 4 (OCT4) and sex determining region Y-box 2 (SOX2) to modulate a histone mark associated with active transcription, trimethylation of lysine 4 on histone H3 protein subunit (H3K4me3).
    Title: PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.
  4. These findings establish a unique PHF20-mediated link between MOF histone acetyltransferase (HAT), p53, and dimethylated lysine 4 of histone H3, and suggest a model for rapid spreading of H4K16ac-enriched open chromatin.
    Title: PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
  5. PHF20 may play an important role in Non-small-cell lung cancer (NSCLC).
    Title: Expression of PHF20 protein contributes to good prognosis of NSCLC and is associated with Bax expression.
  6. Along with the PHF20/MOF complex, G9a links the crosstalk between ERalpha methylation and histone acetylation that governs the epigenetic regulation of hormonal gene expression.
    Title: G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.
  7. suggests a del(20q)-independent decrease in PHF20 expression in primary myelofibrosis
    Title: Altered expression of tumor suppressor PHF20 in myeloproliferative neoplasms.
  8. Plant homeodomain finger protein 20 (PHF20) maintains NF-kappaB in an active state in the nucleus by inhibiting the interaction between PP2A and p65.
    Title: PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.
  9. PHF20 is a novel substrate for PKB and its phosphorylation by PKB plays an important role in tumorigenesis via regulating of p53 mediated signaling.
    Title: PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.
  10. Association with PHF20 promotes stabilization and activation of p53 by diminishing Mdm2-mediated p53 ubiquitylation and degradation.
    Title: PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ33479

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MLL1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NSL complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
PHD finger protein 20
Names
glioma-expressed antigen 2
hepatocellular carcinoma-associated antigen 58
novel zinc finger protein
transcription factor TZP
tudor domain containing 20A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016436.5 → NP_057520.2  PHD finger protein 20

    See identical proteins and their annotated locations for NP_057520.2

    Status: VALIDATED

    Source sequence(s)
    AL109965, AL137330, AY027523, BC093405
    Consensus CDS
    CCDS13268.1
    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22
    Related
    ENSP00000363124.3, ENST00000374012.8
    Conserved Domains (4) summary
    cd04508
    Location:90 → 135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15634
    Location:654 → 697
    PHD_PHF20; PHD finger found in PHD finger protein 20 (PHF20)
    pfam12618
    Location:176 → 259
    DUF3776; Protein of unknown function (DUF3776)
    cl17705
    Location:3 → 68
    MBT; mbt repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    35772015..35950370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440180.1 → XP_047296136.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22

  2. XM_017027868.3 → XP_016883357.1  PHD finger protein 20 isoform X2

  3. XM_047440181.1 → XP_047296137.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22

  4. XM_047440182.1 → XP_047296138.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22

  5. XM_047440184.1 → XP_047296140.1  PHD finger protein 20 isoform X4

  6. XM_047440183.1 → XP_047296139.1  PHD finger protein 20 isoform X3

  7. XM_005260421.4 → XP_005260478.1  PHD finger protein 20 isoform X4

    See identical proteins and their annotated locations for XP_005260478.1

    Conserved Domains (1) summary
    cl22851
    Location:251 → 294
    PHD_SF; PHD finger superfamily

  8. XM_047440186.1 → XP_047296142.1  PHD finger protein 20 isoform X4

  9. XM_047440185.1 → XP_047296141.1  PHD finger protein 20 isoform X4

  10. XM_011528844.3 → XP_011527146.1  PHD finger protein 20 isoform X4

    See identical proteins and their annotated locations for XP_011527146.1

    Conserved Domains (1) summary
    cl22851
    Location:251 → 294
    PHD_SF; PHD finger superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    37493003..37671367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323469.1 → XP_054179444.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22

  2. XM_054323472.1 → XP_054179447.1  PHD finger protein 20 isoform X2

  3. XM_054323470.1 → XP_054179445.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22

  4. XM_054323471.1 → XP_054179446.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22

  5. XM_054323474.1 → XP_054179449.1  PHD finger protein 20 isoform X4

  6. XM_054323473.1 → XP_054179448.1  PHD finger protein 20 isoform X3

  7. XM_054323475.1 → XP_054179450.1  PHD finger protein 20 isoform X4

  8. XM_054323478.1 → XP_054179453.1  PHD finger protein 20 isoform X4

  9. XM_054323477.1 → XP_054179452.1  PHD finger protein 20 isoform X4

  10. XM_054323476.1 → XP_054179451.1  PHD finger protein 20 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BVI0.2 GenPept UniProtKB/Swiss-Prot:Q9BVI0

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