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F11R F11 receptor [ Homo sapiens (human) ]

Gene ID: 50848, updated on 3-Nov-2024

Summary

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Official Symbol
F11Rprovided by HGNC
Official Full Name
F11 receptorprovided by HGNC
Primary source
HGNC:HGNC:14685
See related
Ensembl:ENSG00000158769 MIM:605721; AllianceGenome:HGNC:14685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 46.3), small intestine (RPKM 31.8) and 24 other tissues See more
Orthologs
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Genomic context

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See F11R in Genome Data Viewer
Location:
1q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (160995211..161021152, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160132277..160158230, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160965001..160990942, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904441 Neighboring gene uncharacterized LOC101928372 Neighboring gene intelectin 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:160931121-160931639 Neighboring gene Sharpr-MPRA regulatory region 3396 Neighboring gene Sharpr-MPRA regulatory region 578 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:160960931-160961769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160975781-160976290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160976291-160976800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160976801-160977309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:160985695-160986292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:160991075-160991672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161002153-161003089 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161004943-161005449 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161005450-161005955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1970 Neighboring gene GLR5 pseudogene 2 Neighboring gene thiosulfate sulfurtransferase like domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface. Monteiro AC, et al. Mol Biol Cell, 2014 May. PMID 24672055, Free PMC Article
  2. Transcription and translation of human F11R gene are required for an initial step of atherogenesis induced by inflammatory cytokines. Azari BM, et al. J Transl Med, 2011 Jun 26. PMID 21703019, Free PMC Article
  3. Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion. Babinska A, et al. Thromb Haemost, 2002 Apr. PMID 12008956
  4. Low expression of junctional adhesion molecule A is associated with metastasis and poor survival in pancreatic cancer. Fong D, et al. Ann Surg Oncol, 2012 Dec. PMID 22549289
  5. A novel role for junctional adhesion molecule-A in tumor proliferation: modulation by an anti-JAM-A monoclonal antibody. Goetsch L, et al. Int J Cancer, 2013 Mar 15. PMID 22886345

See all (172) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound By Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells.
    Title: JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound By Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells.
  2. A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast Cancer.
    Title: A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast Cancer.
  3. MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer.
    Title: MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer.
  4. Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation.
    Title: Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation.
  5. LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
    Title: LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
  6. Association of F11R polymorphisms and gene expression with primary Sjogren's syndrome patients.
    Title: Association of F11R polymorphisms and gene expression with primary Sjögren's syndrome patients.
  7. Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity.
    Title: Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity.
  8. Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury.
    Title: Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury.
  9. Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa.
    Title: Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa.
  10. Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155.
    Title: Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155.
Submit: New GeneRIF Correction See all GeneRIFs (102)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of F11R PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cannabinoid inhibits HIV-1 gp120-induced tight junction protein down-regulation of ZO-1, claudin-5, and JAM-1 in human brain micro vascular endothelial cells (HBMEC) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: TSTD1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cadherin binding HDA PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to mechanical stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of endothelial intestinal barrier IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in intestinal absorption IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intestinal absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of blood-brain barrier NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in memory T cell extravasation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of platelet aggregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to bicellular tight junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of membrane permeability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane permeability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell junction TAS
Traceable Author Statement
more info
  
located_in cell-cell junction TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in tight junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
junctional adhesion molecule A
Names
junctional adhesion molecule 1
platelet F11 receptor
platelet adhesion molecule 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348091.2 → NP_001335020.1  junctional adhesion molecule A isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK304412, AL591806
    Consensus CDS
    CCDS86026.1
    UniProtKB/TrEMBL
    Q9Y5B2
    Related
    ENSP00000440812.1, ENST00000537746.1
    Conserved Domains (1) summary
    pfam13927
    Location:78 → 167
    Ig_3; Immunoglobulin domain

  2. NM_001382727.1 → NP_001369656.1  junctional adhesion molecule A isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL591806
    UniProtKB/TrEMBL
    B7Z5W1, E7EPV8
    Conserved Domains (2) summary
    cd20946
    Location:30 → 129
    IgV_1_JAM1-like; First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains
    cd20950
    Location:135 → 231
    IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains

  3. NM_001382730.1 → NP_001369659.1  junctional adhesion molecule A isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AL591806
    UniProtKB/TrEMBL
    Q9Y5B2
    Conserved Domains (2) summary
    cd20946
    Location:30 → 129
    IgV_1_JAM1-like; First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains
    cd20950
    Location:135 → 231
    IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains

  4. NM_001382733.1 → NP_001369662.1  junctional adhesion molecule A isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AL591806
    UniProtKB/TrEMBL
    Q9Y5B2
    Conserved Domains (2) summary
    cd20946
    Location:30 → 129
    IgV_1_JAM1-like; First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains
    cd20950
    Location:135 → 231
    IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains

  5. NM_001382734.1 → NP_001369663.1  junctional adhesion molecule A isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AL591806
    UniProtKB/TrEMBL
    Q9Y5B2
    Conserved Domains (3) summary
    cd00096
    Location:22 → 30
    Ig; Ig strand B [structural motif]
    cd20950
    Location:112 → 208
    IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains
    cl11960
    Location:22 → 106
    Ig; Immunoglobulin domain

  6. NM_016946.6 → NP_058642.1  junctional adhesion molecule A isoform 1 precursor

    See identical proteins and their annotated locations for NP_058642.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF172398, AL591806, DA907460
    Consensus CDS
    CCDS1213.1
    UniProtKB/Swiss-Prot
    B7Z941, Q9Y624
    UniProtKB/TrEMBL
    Q6FIB4, Q9Y5B2
    Related
    ENSP00000357005.5, ENST00000368026.11
    Conserved Domains (2) summary
    smart00410
    Location:36 → 125
    IG_like; Immunoglobulin like
    pfam13927
    Location:135 → 216
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    160995211..161021152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160132277..160158230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144501.1: Suppressed sequence

    Description
    NM_144501.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_144502.1: Suppressed sequence

    Description
    NM_144502.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  3. NM_144503.1: Suppressed sequence

    Description
    NM_144503.1: This RefSeq was permanently suppressed because it is now thought that it represents a rare read-through transcript.

  4. NM_144504.1: Suppressed sequence

    Description
    NM_144504.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y624.1 GenPept UniProtKB/Swiss-Prot:Q9Y624

Gene LinkOut

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Chemical Information
Molecular Biology Databases
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