U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [ Homo sapiens (human) ]

Gene ID: 50807, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ASAP1provided by HGNC
Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1provided by HGNC
Primary source
HGNC:HGNC:2720
See related
Ensembl:ENSG00000153317 MIM:605953; AllianceGenome:HGNC:2720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP; PAG2; AMAP1; DDEF1; ZG14P; CENTB4
Summary
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 18.3), spleen (RPKM 15.5) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ASAP1 in Genome Data Viewer
Location:
8q24.21-q24.22
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (130052104..130443674, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (131178779..131571038, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (131064350..131455920, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CYFIP related Rac1 interactor B Neighboring gene uncharacterized LOC124902025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19544 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131054337-131055152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27979 Neighboring gene RNA, U7 small nuclear 181 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131067248-131067450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131081877-131082759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131098365-131098897 Neighboring gene microRNA 5194 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131110363-131110520 Neighboring gene RNA, U6 small nuclear 1255, pseudogene Neighboring gene ASAP1 intronic transcript 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27981 Neighboring gene small nucleolar RNA SNORA12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:131216140-131217109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27982 Neighboring gene uncharacterized LOC124902027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27984 Neighboring gene NANOG hESC enhancer GRCh37_chr8:131323031-131323532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131345596-131346175 Neighboring gene ASAP1 intronic transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131370073-131371035 Neighboring gene uncharacterized LOC124902026 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:131380037-131380536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131388200-131388776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131431296-131431799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19554 Neighboring gene Sharpr-MPRA regulatory region 3250 Neighboring gene uncharacterized LOC105375758 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:131540148-131541347 Neighboring gene NFE2L2 motif-containing MPRA enhancer 239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27988 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101181 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:131739458-131740657 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131759497-131759683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19555 Neighboring gene uncharacterized LOC105375762 Neighboring gene adenylate cyclase 8

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains. Che MM, et al. Cell Signal, 2005 Oct. PMID 16038802
  2. Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression. He J, et al. Oncogene, 2020 May. PMID 32235890, Free PMC Article
  3. The BAR domain of the Arf GTPase-activating protein ASAP1 directly binds actin filaments. Chen PW, et al. J Biol Chem, 2020 Aug 7. PMID 32444496, Free PMC Article
  4. IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells. Miyata M, et al. Cell Cycle, 2008 Oct. PMID 18843202
  5. Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1. Jian X, et al. J Biol Chem, 2009 Jan 16. PMID 19017632, Free PMC Article

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
    Title: miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
  2. ASAP1 Expression in Invasive Breast Cancer and Its Prognostic Role.
    Title: ASAP1 Expression in Invasive Breast Cancer and Its Prognostic Role.
  3. An Uncharacterised lncRNA Coded by the ASAP1 Locus Is Downregulated in Serum of Type 2 Diabetes Mellitus Patients.
    Title: An Uncharacterised lncRNA Coded by the ASAP1 Locus Is Downregulated in Serum of Type 2 Diabetes Mellitus Patients.
  4. ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancer.
    Title: ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancer.
  5. Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population.
    Title: Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population.
  6. Clinicopathological Implications of ASAP1 Expression in Hepatocellular Carcinoma.
    Title: Clinicopathological Implications of ASAP1 Expression in Hepatocellular Carcinoma.
  7. Loss of ASAP1 in the MMTV-PyMT model of luminal breast cancer activates AKT, accelerates tumorigenesis, and promotes metastasis.
    Title: Loss of ASAP1 in the MMTV-PyMT model of luminal breast cancer activates AKT, accelerates tumorigenesis, and promotes metastasis.
  8. ASAP1 regulates the uptake of Mycobacterium tuberculosis H37Ra in THP1-derived macrophages by remodeling actin cytoskeleton.
    Title: ASAP1 regulates the uptake of Mycobacterium tuberculosis H37Ra in THP1-derived macrophages by remodeling actin cytoskeleton.
  9. High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer.
    Title: High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer.
  10. Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis.
    Title: Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IC
Inferred by Curator
more info
 PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cilium assembly IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cilium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in podosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Names
130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
ADP-ribosylation factor-directed GTPase-activating protein 1
ARF GTPase-activating protein 1
DEF-1
PIP2-dependent ARF1 GAP
centaurin, beta 4
development and differentiation-enhancing factor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030354.1 RefSeqGene

    Range
    4987..396557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001247996.2 → NP_001234925.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001234925.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon (with an in-frame AUG) in the 5' region compared to variant 1. This results in translation initiation from an alternate start site, and a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB033075, AI494058, AP005856, BC144493, DA319233
    Consensus CDS
    CCDS75788.1
    UniProtKB/TrEMBL
    A0A0A0MRE5, H0YBF7
    Related
    ENSP00000350297.2, ENST00000357668.2
    Conserved Domains (8) summary
    cd07641
    Location:47 → 261
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1064 → 1120
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:594 → 682
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:309 → 415
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:319 → 404
    PH; PH domain
    pfam01412
    Location:432 → 548
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:575 → 660
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:594 → 627
    ANK; ANK repeat [structural motif]

  2. NM_001362924.1 → NP_001349853.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB033075, AI494058, BC144493, BQ645913, DA315979, DA319233, DA416332
    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1074 → 1130
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604 → 692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319 → 425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604 → 637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442 → 558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:727 → 1063
    Atrophin-1; Atrophin-1 family

  3. NM_001362925.2 → NP_001349854.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AB033075, AI494058, AP005856, BC144493, BG748866, DA315979, DA319233, DA416332
    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1017 → 1073
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604 → 692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319 → 425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604 → 637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442 → 558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:730 → 1006
    Atrophin-1; Atrophin-1 family

  4. NM_001362926.2 → NP_001349855.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AB033075, AI494058, AP005856, BC144493, BG118567, BG748866, DA315979, DA319233, DA416332
    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1014 → 1070
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:601 → 689
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:316 → 422
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:601 → 634
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:439 → 555
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:727 → 1003
    Atrophin-1; Atrophin-1 family

  5. NM_018482.4 → NP_060952.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_060952.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
    Source sequence(s)
    AB033075, AI494058, AP005856, BC137135, DA319233
    Consensus CDS
    CCDS6362.1
    UniProtKB/Swiss-Prot
    B2RNV3, Q9ULH1
    UniProtKB/TrEMBL
    H0YBF7
    Related
    ENSP00000429900.1, ENST00000518721.6
    Conserved Domains (8) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1071 → 1127
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:601 → 689
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:316 → 422
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:326 → 411
    PH; PH domain
    pfam01412
    Location:439 → 555
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:582 → 667
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:601 → 634
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    130052104..130443674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421810.1 → XP_047277766.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X14

  2. XM_047421806.1 → XP_047277762.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

  3. XM_017013468.2 → XP_016868957.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (8) summary
    cd11965
    Location:1015 → 1071
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:545 → 633
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:260 → 366
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:270 → 355
    PH; PH domain
    pfam01412
    Location:383 → 499
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:526 → 611
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:545 → 578
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1 → 209
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_047421804.1 → XP_047277760.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

  5. XM_047421800.1 → XP_047277756.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B2RNV3, Q9ULH1

  6. XM_047421799.1 → XP_047277755.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

  7. XM_047421805.1 → XP_047277761.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

  8. XM_011517052.3 → XP_011515354.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011515354.1

    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1074 → 1130
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604 → 692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319 → 425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604 → 637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442 → 558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:727 → 1063
    Atrophin-1; Atrophin-1 family

  9. XM_047421807.1 → XP_047277763.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

  10. XM_047421808.1 → XP_047277764.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X12

  11. XM_047421801.1 → XP_047277757.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MRE5

  12. XM_011517053.2 → XP_011515355.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011515355.1

    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (8) summary
    cd07641
    Location:47 → 261
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1067 → 1123
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:597 → 685
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:312 → 418
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:322 → 407
    PH; PH domain
    pfam01412
    Location:435 → 551
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:578 → 663
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:597 → 630
    ANK; ANK repeat [structural motif]

  13. XM_006716565.3 → XP_006716628.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (8) summary
    cd11965
    Location:1018 → 1074
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:548 → 636
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:263 → 369
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:273 → 358
    PH; PH domain
    pfam01412
    Location:386 → 502
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:529 → 614
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:548 → 581
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1 → 212
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  14. XM_017013467.3 → XP_016868956.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    H0YBF7

  15. XM_047421809.1 → XP_047277765.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X13

  16. XM_047421802.1 → XP_047277758.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

  17. XM_047421803.1 → XP_047277759.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

  18. XM_047421811.1 → XP_047277767.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X15

    Related
    ENSP00000429391.1, ENST00000524124.5

  19. XM_047421812.1 → XP_047277768.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    131178779..131571038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360532.1 → XP_054216507.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X14

  2. XM_054360528.1 → XP_054216503.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

  3. XM_054360525.1 → XP_054216500.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X9

  4. XM_054360526.1 → XP_054216501.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

  5. XM_054360517.1 → XP_054216492.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

  6. XM_054360515.1 → XP_054216490.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

  7. XM_054360527.1 → XP_054216502.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

  8. XM_054360516.1 → XP_054216491.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

  9. XM_054360529.1 → XP_054216504.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

  10. XM_054360518.1 → XP_054216493.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

  11. XM_054360519.1 → XP_054216494.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

  12. XM_054360530.1 → XP_054216505.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X12

  13. XM_054360520.1 → XP_054216495.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X17

  14. XM_054360523.1 → XP_054216498.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

  15. XM_054360521.1 → XP_054216496.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

  16. XM_054360531.1 → XP_054216506.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X13

  17. XM_054360522.1 → XP_054216497.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

  18. XM_054360524.1 → XP_054216499.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

  19. XM_054360533.1 → XP_054216508.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X15

  20. XM_054360534.1 → XP_054216509.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X16

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULH1.4 GenPept UniProtKB/Swiss-Prot:Q9ULH1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous