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ARHGEF25 Rho guanine nucleotide exchange factor 25 [ Bos taurus (domestic cattle) ]

Gene ID: 506075, updated on 10-Oct-2024

Summary

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Official Symbol
ARHGEF25provided by VGNC
Official Full Name
Rho guanine nucleotide exchange factor 25provided by VGNC
Primary source
VGNC:VGNC:26112
See related
BGD:BT15763; Ensembl:ENSBTAG00000018003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
GEFT
Orthologs
human mouse all
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Genomic context

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See ARHGEF25 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (55872522..55879741, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 1 Neighboring gene solute carrier family 26 member 10 Neighboring gene deltex E3 ubiquitin ligase 3 Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 25
Names
RAC/CDC42 exchange factor
Rho guanine nucleotide exchange factor (GEF) 25
RhoA/RAC/CDC42 exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024481.2 → NP_001019652.2  rho guanine nucleotide exchange factor 25

    See identical proteins and their annotated locations for NP_001019652.2

    Status: VALIDATED

    Source sequence(s)
    NKLS02000005
    UniProtKB/TrEMBL
    A0A3Q1LKU4, F1MWU7
    Related
    ENSBTAP00000023960.5, ENSBTAT00000023960.7
    Conserved Domains (2) summary
    cd13241
    Location:378 → 520
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 373
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    55872522..55879741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015471073.3 → XP_015326559.1  rho guanine nucleotide exchange factor 25 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1MR77, Q5EAB1
    Conserved Domains (2) summary
    cd13241
    Location:233 → 375
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:58 → 228
    RhoGEF; RhoGEF domain

  2. XM_059886192.1 → XP_059742175.1  rho guanine nucleotide exchange factor 25 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1N6F4
    Related
    ENSBTAP00000066043.2, ENSBTAT00000072165.2

  3. XM_059886193.1 → XP_059742176.1  rho guanine nucleotide exchange factor 25 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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