FOXP3 forkhead box P3 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: FOXP3provided by VGNC
Official Full Name: forkhead box P3provided by VGNC
Primary source: VGNC:VGNC:29102
See related: BGD:BT11649; Ensembl:ENSBTAG00000013279
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (87289535..87308827, complement)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GWAS identified a maternal variant in the upstream region of FOXP3 that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using embryo transfer. The variant affected the level of FOXP3 mRNA expression.
Title: Maternal variant in the upstream of FOXP3 gene on the X chromosome is associated with recurrent infertility in Japanese Black cattle.
Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4.
Title: Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
regulatory role in intramuscular fat deposition
Title: A marker-derived gene network reveals the regulatory role of PPARGC1A, HNF4G, and FOXP3 in intramuscular fat deposition of beef cattle.
The expression of Foxp3 in CD4(+) T cells from persistent lymphocytotic cattle was significantly increased.
Title: Expression analysis of Foxp3 in T cells from bovine leukemia virus infected cattle.
There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.
Title: Foxp3 expression in bovine CD8+ T cells is associated with the intensity of CD25 expression.
identification of Foxp3 expression in Treg cells
Title: Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry.
These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
Title: Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: forkhead box protein P3

Names: forkhead/winged helix transcription factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045933.1 → NP_001039398.1 forkhead box protein P3

See identical proteins and their annotated locations for NP_001039398.1

Status: PROVISIONAL

Source sequence(s)

DQ322170

UniProtKB/TrEMBL

F1MSV7, Q2LEZ0

Conserved Domains (2) summary

cd00059
Location:337 → 409

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:193 → 260

FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

Range

87289535..87308827 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024987814.2 → XP_024843582.1 forkhead box protein P3 isoform X1

UniProtKB/TrEMBL

A0AAA9SEU9

Related

ENSBTAP00000017660.6, ENSBTAT00000017660.7

Conserved Domains (2) summary

pfam00250
Location:368 → 441

Forkhead; Forkhead domain

pfam16159
Location:224 → 291

FOXP-CC; FOXP coiled-coil domain
XM_024987816.2 → XP_024843584.1 forkhead box protein P3 isoform X2

UniProtKB/TrEMBL

F1MSV7

Related

ENSBTAP00000064761.2, ENSBTAT00000087462.2

Conserved Domains (3) summary

pfam00250
Location:351 → 424

Forkhead; Forkhead domain

pfam16159
Location:207 → 274

FOXP-CC; FOXP coiled-coil domain

cl26464
Location:12 → 211

Atrophin-1; Atrophin-1 family