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PAK1 p21 (RAC1) activated kinase 1 [ Homo sapiens (human) ]

Gene ID: 5058, updated on 14-Nov-2024

Summary

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Official Symbol
PAK1provided by HGNC
Official Full Name
p21 (RAC1) activated kinase 1provided by HGNC
Primary source
HGNC:HGNC:8590
See related
Ensembl:ENSG00000149269 MIM:602590; AllianceGenome:HGNC:8590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IDDMSSD; p65-PAK; PAKalpha; alpha-PAK
Summary
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Expression
Ubiquitous expression in brain (RPKM 55.5), thyroid (RPKM 19.6) and 23 other tissues See more
Orthologs
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Genomic context

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See PAK1 in Genome Data Viewer
Location:
11q13.5-q14.1
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (77322017..77530009, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (77254590..77463028, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77033062..77185139, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene TOMM20 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr11:77106673-77107174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5304 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77159760-77160530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77184247-77185163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:77189428-77189933 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:77190945-77191449 Neighboring gene Sharpr-MPRA regulatory region 3332 Neighboring gene uncharacterized LOC124902722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5307 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:77270938-77272137 Neighboring gene RNA, U7 small nuclear 59 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
    Title: Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
  2. Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
    Title: Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
  3. Targetable leukaemia dependency on noncanonical PI3Kgamma signalling.
    Title: Targetable leukaemia dependency on noncanonical PI3Kγ signalling.
  4. PAK1 Promotes Inflammation Induced by Sepsis through the Snail/CXCL2 Signaling Pathway.
    Title: PAK1 Promotes Inflammation Induced by Sepsis through the Snail/CXCL2 Signaling Pathway.
  5. A PAK1 Mutational Hotspot Within the Regulatory CRIPaK Domain is Associated With Severe Neurodevelopmental Disorders in Children.
    Title: A PAK1 Mutational Hotspot Within the Regulatory CRIPaK Domain is Associated With Severe Neurodevelopmental Disorders in Children.
  6. PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis.
    Title: PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis.
  7. A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity.
    Title: A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity.
  8. Clinicopathological significance and the associated signaling pathway of p21-activated kinase 1 (PAK1) in colorectal cancer.
    Title: Clinicopathological significance and the associated signaling pathway of p21-activated kinase 1 (PAK1) in colorectal cancer.
  9. Activation of oncogenic signaling kinase PAK1 by ionising radiation confers an aggressive phenotype in head and neck squamous cell carcinoma.
    Title: Activation of oncogenic signaling kinase PAK1 by ionising radiation confers an aggressive phenotype in head and neck squamous cell carcinoma.
  10. PAK1 and Therapy Resistance in Melanoma.
    Title: PAK1 and Therapy Resistance in Melanoma.
Submit: New GeneRIF Correction See all GeneRIFs (310)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual developmental disorder with macrocephaly, seizures, and speech delay
MedGen: C4748428 OMIM: 618158 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface PubMed
Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
nef HIV-1 Nef induces phosphorylation of MEK1 at position serine 298, which depends on Pak and Rac activity. The SH3 region mutation 72PXXP/AXXA75 in Nef results in loss of Pak association which decreases Nef-induced MEK1 phosphorylation PubMed
nef HIV-1 Nef mutants LLAA and delta12-39 significantly impairs downregulation of CD4. Nef LLAA mutant fails to interact with the endocytic machinery and Nef delta12-39 mutant lacks the interaction with the Nef-associated kinase complex PubMed
nef The mutation of all four glutamates (amino acids 62-65) to alanine in HIV-1 Nef impairs the ability of Nef to regulate p21-activated protein kinase and enhance viral particle infectivity PubMed
nef HIV-1 Nef binding and activation of the PAK-related kinase and phosphorylation of its substrate (a complex composed of PIX and p95) are readily detected in both infected primary T lymphocytes and macrophages PubMed
nef HIV-1 Nef-mediated p21-activated kinase (PAK) activation involves the binding of Nef and phosphatidylinositol 3-kinase (PI3K) PubMed
nef The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases PubMed
nef HIV-1 Nef-mediated activation of a PAK-related kinase correlates with the induction of high virus loads and the development of AIDS in infected rhesus macaques PubMed
nef The association of HIV-1 Nef with the cellular serine kinase PAK enhances efficient proviral DNA synthesis and virion infectivity PubMed
nef A cellular serine kinase is found to specifically associate with HIV-1 Nef; proteins of 62 kDa and 72 kDa, which coimmunoprecipitated with Nef, are phosphorylated in in vitro kinase assays PubMed
Tat tat Uptake of the HIV-1 Tat protein is regulated by PAK1 activity in epithelial cells PubMed
tat HIV-1 Tat induces actin cytoskeletal rearrangements through p21-activated kinase 1 (PAK1) and downstream activation of the endothelial NADPH oxidase, an effect that is lost by introduction of mutations into the Tat cysteine-rich or basic domains PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130000, MGC130001

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables collagen binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
  
NOT involved_in MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in hepatocyte growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell proliferation involved in contact inhibition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase PAK 1
Names
STE20 homolog, yeast
p21 protein (Cdc42/Rac)-activated kinase 1
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
NP_001122092.1
NP_001363197.1
NP_001363198.1
NP_001363199.1
NP_001363200.1
NP_001363201.1
NP_001363202.1
NP_001363203.1
NP_001363204.1
NP_001363205.1
NP_001363206.1
NP_001363207.1
NP_001363208.1
NP_001363209.1
NP_001363210.1
NP_001363211.1
NP_001363212.1
NP_001363213.1
NP_001363214.1
NP_001363215.1
NP_001363216.1
NP_001363217.1
NP_001363218.1
NP_001363219.1
NP_001363220.1
NP_001363221.1
NP_001363222.1
NP_001363223.1
NP_001363224.1
NP_001363230.1
NP_001363231.1
NP_001363232.1
NP_001363233.1
NP_001363234.1
NP_002567.3
XP_024304325.1
XP_024304326.1
XP_024304327.1
XP_024304328.1
XP_047283002.1
XP_047283003.1
XP_047283004.1
XP_047283005.1
XP_047283006.1
XP_047283007.1
XP_047283008.1
XP_047283009.1
XP_047283010.1
XP_054224984.1
XP_054224985.1
XP_054224986.1
XP_054224987.1
XP_054224988.1
XP_054224989.1
XP_054224990.1
XP_054224991.1
XP_054224992.1
XP_054224993.1
XP_054224994.1
XP_054224995.1
XP_054224996.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029900.3 RefSeqGene

    Range
    60915..212992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128620.2 → NP_001122092.1  serine/threonine-protein kinase PAK 1 isoform 1

    See identical proteins and their annotated locations for NP_001122092.1

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS44687.1
    UniProtKB/TrEMBL
    A8KAN3
    Related
    ENSP00000278568.4, ENST00000278568.8
    Conserved Domains (2) summary
    cd06647
    Location:262 → 517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain

  2. NM_001376268.1 → NP_001363197.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS44687.1
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06647
    Location:262 → 517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain

  3. NM_001376269.1 → NP_001363198.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS44687.1
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06647
    Location:262 → 517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain

  4. NM_001376270.1 → NP_001363199.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS44687.1
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06647
    Location:262 → 517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain

  5. NM_001376271.1 → NP_001363200.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS44687.1
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06647
    Location:262 → 517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain

  6. NM_001376272.1 → NP_001363201.1  serine/threonine-protein kinase PAK 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:256 → 551
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 135
    PBD; P21-Rho-binding domain

  7. NM_001376273.1 → NP_001363202.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  8. NM_001376274.1 → NP_001363203.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  9. NM_001376275.1 → NP_001363204.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  10. NM_001376276.1 → NP_001363205.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  11. NM_001376277.1 → NP_001363206.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  12. NM_001376278.1 → NP_001363207.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  13. NM_001376279.1 → NP_001363208.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  14. NM_001376280.1 → NP_001363209.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  15. NM_001376281.1 → NP_001363210.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  16. NM_001376282.1 → NP_001363211.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  17. NM_001376283.1 → NP_001363212.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  18. NM_001376284.1 → NP_001363213.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  19. NM_001376285.1 → NP_001363214.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  20. NM_001376286.1 → NP_001363215.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  21. NM_001376287.1 → NP_001363216.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  22. NM_001376288.1 → NP_001363217.1  serine/threonine-protein kinase PAK 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS91545.1
    UniProtKB/TrEMBL
    A8KAN3, B3KNX7
    Related
    ENSP00000433423.1, ENST00000530617.5
    Conserved Domains (2) summary
    cd06647
    Location:262 → 518
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain

  23. NM_001376289.1 → NP_001363218.1  serine/threonine-protein kinase PAK 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain
    cl21453
    Location:262 → 471
    PKc_like; Protein Kinases, catalytic domain

  24. NM_001376290.1 → NP_001363219.1  serine/threonine-protein kinase PAK 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain
    cl21453
    Location:249 → 503
    PKc_like; Protein Kinases, catalytic domain

  25. NM_001376291.1 → NP_001363220.1  serine/threonine-protein kinase PAK 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain
    cl21453
    Location:249 → 503
    PKc_like; Protein Kinases, catalytic domain

  26. NM_001376292.1 → NP_001363221.1  serine/threonine-protein kinase PAK 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain
    cl21453
    Location:249 → 498
    PKc_like; Protein Kinases, catalytic domain

  27. NM_001376293.1 → NP_001363222.1  serine/threonine-protein kinase PAK 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain
    cl21453
    Location:249 → 498
    PKc_like; Protein Kinases, catalytic domain

  28. NM_001376294.1 → NP_001363223.1  serine/threonine-protein kinase PAK 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain
    cl21453
    Location:259 → 472
    PKc_like; Protein Kinases, catalytic domain

  29. NM_001376295.1 → NP_001363224.1  serine/threonine-protein kinase PAK 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain
    cl21453
    Location:274 → 485
    PKc_like; Protein Kinases, catalytic domain

  30. NM_001376301.1 → NP_001363230.1  serine/threonine-protein kinase PAK 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/TrEMBL
    B7Z3K0
    Conserved Domains (1) summary
    cd06654
    Location:166 → 461
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

  31. NM_001376302.1 → NP_001363231.1  serine/threonine-protein kinase PAK 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Consensus CDS
    CCDS91544.1
    UniProtKB/TrEMBL
    B7Z3K0, E9PM17
    Related
    ENSP00000433211.1, ENST00000528203.5
    Conserved Domains (1) summary
    cd06647
    Location:164 → 419
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase

  32. NM_001376303.1 → NP_001363232.1  serine/threonine-protein kinase PAK 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd01093
    Location:73 → 118
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:198 → 448
    PKc_like; Protein Kinases, catalytic domain

  33. NM_001376304.1 → NP_001363233.1  serine/threonine-protein kinase PAK 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/TrEMBL
    B7Z3K0
    Conserved Domains (1) summary
    cd06654
    Location:151 → 446
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

  34. NM_001376305.1 → NP_001363234.1  serine/threonine-protein kinase PAK 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/TrEMBL
    B7Z3K0
    Conserved Domains (1) summary
    cd06654
    Location:151 → 446
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

  35. NM_002576.5 → NP_002567.3  serine/threonine-protein kinase PAK 1 isoform 2

    See identical proteins and their annotated locations for NP_002567.3

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Related
    ENSP00000348696.4, ENST00000356341.8
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

RNA

  1. NR_164797.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000486

  2. NR_164798.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000486

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    77322017..77530009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448560.2 → XP_024304328.1  serine/threonine-protein kinase PAK 1 isoform X4

    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06654
    Location:249 → 544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74 → 132
    PBD; P21-Rho-binding domain

  2. XM_047427054.1 → XP_047283010.1  serine/threonine-protein kinase PAK 1 isoform X4

    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79

  3. XM_047427049.1 → XP_047283005.1  serine/threonine-protein kinase PAK 1 isoform X3

  4. XM_047427051.1 → XP_047283007.1  serine/threonine-protein kinase PAK 1 isoform X3

  5. XM_047427048.1 → XP_047283004.1  serine/threonine-protein kinase PAK 1 isoform X3

  6. XM_024448559.2 → XP_024304327.1  serine/threonine-protein kinase PAK 1 isoform X3

    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06647
    Location:262 → 517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain

  7. XM_047427053.1 → XP_047283009.1  serine/threonine-protein kinase PAK 1 isoform X4

    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79

  8. XM_047427050.1 → XP_047283006.1  serine/threonine-protein kinase PAK 1 isoform X3

  9. XM_024448557.2 → XP_024304325.1  serine/threonine-protein kinase PAK 1 isoform X3

    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06647
    Location:262 → 517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain

  10. XM_047427047.1 → XP_047283003.1  serine/threonine-protein kinase PAK 1 isoform X2

  11. XM_047427046.1 → XP_047283002.1  serine/threonine-protein kinase PAK 1 isoform X1

  12. XM_047427052.1 → XP_047283008.1  serine/threonine-protein kinase PAK 1 isoform X3

  13. XM_024448558.2 → XP_024304326.1  serine/threonine-protein kinase PAK 1 isoform X3

    UniProtKB/TrEMBL
    A8KAN3
    Conserved Domains (2) summary
    cd06647
    Location:262 → 517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74 → 128
    PBD; P21-Rho-binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    77254590..77463028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369020.1 → XP_054224995.1  serine/threonine-protein kinase PAK 1 isoform X4

    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79

  2. XM_054369019.1 → XP_054224994.1  serine/threonine-protein kinase PAK 1 isoform X4

    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79

  3. XM_054369012.1 → XP_054224987.1  serine/threonine-protein kinase PAK 1 isoform X3

  4. XM_054369017.1 → XP_054224992.1  serine/threonine-protein kinase PAK 1 isoform X3

  5. XM_054369011.1 → XP_054224986.1  serine/threonine-protein kinase PAK 1 isoform X3

  6. XM_054369021.1 → XP_054224996.1  serine/threonine-protein kinase PAK 1 isoform X4

    UniProtKB/Swiss-Prot
    O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79

  7. XM_054369013.1 → XP_054224988.1  serine/threonine-protein kinase PAK 1 isoform X3

  8. XM_054369014.1 → XP_054224989.1  serine/threonine-protein kinase PAK 1 isoform X3

  9. XM_054369016.1 → XP_054224991.1  serine/threonine-protein kinase PAK 1 isoform X3

  10. XM_054369010.1 → XP_054224985.1  serine/threonine-protein kinase PAK 1 isoform X2

  11. XM_054369009.1 → XP_054224984.1  serine/threonine-protein kinase PAK 1 isoform X1

  12. XM_054369018.1 → XP_054224993.1  serine/threonine-protein kinase PAK 1 isoform X3

  13. XM_054369015.1 → XP_054224990.1  serine/threonine-protein kinase PAK 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13153.2 GenPept UniProtKB/Swiss-Prot:Q13153

Gene LinkOut

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