NSF N-ethylmaleimide sensitive factor, vesicle fusing ATPase [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: NSFprovided by VGNC
Official Full Name: N-ethylmaleimide sensitive factor, vesicle fusing ATPaseprovided by VGNC
Primary source: VGNC:VGNC:32274
See related: BGD:BT13990; Ensembl:ENSBTAG00000008442
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (45443482..45591602, complement)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report depletion of the ATPase NSF from Golgi membranes with hypo-S-nitrosylation of vasorelevant proteins in endothelial cells exposed to monocrotaline pyrrole.
Title: Depletion of the ATPase NSF from Golgi membranes with hypo-S-nitrosylation of vasorelevant proteins in endothelial cells exposed to monocrotaline pyrrole.

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General gene information

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Markers

SHGC-31272 (e-PCR)
- UniSTS:49188

NSF-1 (e-PCR)
- UniSTS:512128

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in SNARE complex disassembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi stack	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: vesicle-fusing ATPase

Names: N-ethylmaleimide-sensitive factor

NP_001291543.1

EC 3.6.4.6

XP_005221029.1

EC 3.6.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304614.2 → NP_001291543.1 vesicle-fusing ATPase

See identical proteins and their annotated locations for NP_001291543.1

Status: VALIDATED

Source sequence(s)

DV875695, DV885142, DV912908, EE229876, EE341647, EH138216, NKLS02000019

UniProtKB/TrEMBL

A0A3Q1MR04, A0AAA9RYF6

Related

ENSBTAP00000074503.1, ENSBTAT00000083265.1

Conserved Domains (4) summary

smart00382
Location:538 → 670

AAA; ATPases associated with a variety of cellular activities

smart01073
Location:6 → 83

CDC48_N; Cell division protein 48 (CDC48) N-terminal domain

COG0464
Location:142 → 490

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

pfam02933
Location:111 → 159

CDC48_2; Cell division protein 48 (CDC48), domain 2

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

Range

45443482..45591602 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005220972.5 → XP_005221029.1 vesicle-fusing ATPase isoform X1

See identical proteins and their annotated locations for XP_005221029.1

UniProtKB/TrEMBL

A0A3Q1LSE5, A0AAA9RYF6

Related

ENSBTAP00000063277.1, ENSBTAT00000086265.2

Conserved Domains (4) summary

smart00382
Location:254 → 399

AAA; ATPases associated with a variety of cellular activities

smart01072
Location:111 → 183

CDC48_2; Cell division protein 48 (CDC48) domain 2

smart01073
Location:6 → 83

CDC48_N; Cell division protein 48 (CDC48) N-terminal domain

pfam00004
Location:256 → 397

AAA; ATPase family associated with various cellular activities (AAA)