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fbxl22 F-box and leucine-rich repeat protein 22 [ Danio rerio (zebrafish) ]

Gene ID: 503591, updated on 2-Nov-2024

Summary

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Official Symbol
fbxl22provided by ZNC
Official Full Name
F-box and leucine-rich repeat protein 22provided by ZNC
Primary source
ZFIN:ZDB-GENE-050227-1
See related
Ensembl:ENSDARG00000096995 AllianceGenome:ZFIN:ZDB-GENE-050227-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110743
Summary
Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and regulation of cardiac muscle cell contraction. Orthologous to human FBXL22 (F-box and leucine rich repeat protein 22). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See fbxl22 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (26727109..26735957, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (26283907..26292755, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC571902 Neighboring gene uncharacterized LOC137489367 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene si:dkeyp-73b11.8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration. Beisaw A, et al. Circ Res, 2020 Jun 5. PMID 32312172, Free PMC Article
  2. F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. Spaich S, et al. Circ Res, 2012 Dec 7. PMID 22972877
  3. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Takashima S, et al. Mol Genet Metab, 2021 Jul. PMID 34016526
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
F-box and leucine-rich protein 22
NP_001013297.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013279.2 → NP_001013297.1  F-box and leucine-rich protein 22

    See identical proteins and their annotated locations for NP_001013297.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090262
    UniProtKB/TrEMBL
    Q5EAS7
    Related
    ENSDARP00000067113.3, ENSDART00000067114.4
    Conserved Domains (3) summary
    cd09293
    Location:103 → 191
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:116 → 141
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:9 → 48
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    26727109..26735957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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