Acot5 acyl-CoA thioesterase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acot5provided by RGD
Official Full Name: acyl-CoA thioesterase 5provided by RGD
Primary source: RGD:1565917
See related: EnsemblRapid:ENSRNOG00000032508 AllianceGenome:RGD:1565917
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565917
Summary: Predicted to enable acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Predicted to be located in cytosol and peroxisome. Orthologous to human ACOT1 (acyl-CoA thioesterase 1) and ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 137.7), Kidney (RPKM 25.1) and 2 other tissues See more
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Genomic context

Location:: 6q31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (109433062..109439846)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (103701908..103708696)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (107550904..107557688)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 5

NP_001073177.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079709.1 → NP_001073177.1 acyl-coenzyme A thioesterase 5

See identical proteins and their annotated locations for NP_001073177.1

Status: PROVISIONAL

Source sequence(s)

BC128770

UniProtKB/TrEMBL

A0A0G2K4M8, A1A5R4

Related

ENSRNOP00000013760.3, ENSRNOT00000013760.6

Conserved Domains (3) summary

pfam04775
Location:17 → 137

Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

pfam08840
Location:205 → 412

BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

cl21494
Location:137 → 253

Abhydrolase; alpha/beta hydrolases