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Pyurf PIGY upstream open reading frame [ Rattus norvegicus (Norway rat) ]

Gene ID: 502782, updated on 17-Aug-2024

Summary

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Official Symbol
Pyurfprovided by RGD
Official Full Name
PIGY upstream open reading frameprovided by RGD
Primary source
RGD:1565524
See related
AllianceGenome:RGD:1565524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pigy; Prey; Pyurfl1
Summary
Predicted to be involved in GPI anchor biosynthetic process and positive regulation of metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Orthologous to several human genes including PIGY (phosphatidylinositol glycan anchor biosynthesis class Y). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 198.6), Muscle (RPKM 161.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pyurf in Genome Data Viewer
Location:
4q24
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (88832008..88835643)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (87501859..87505494)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (88584242..88587877)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene VOPP1 WW domain binding protein Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Neighboring gene ribosomal protein S7, pseudogene 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Murakami Y, et al. Mol Biol Cell, 2005 Nov. PMID 16162815, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein preY, mitochondrial
Names
PIGY upstream reading frame
PIGY upstream reading frame-like 1
phosphatidylinositol glycan anchor biosynthesis, class Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024370.2 → NP_001019541.1  protein preY, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001019541.1

    Status: VALIDATED

    Source sequence(s)
    BC086361, DV720704, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q5U1Z8
    UniProtKB/TrEMBL
    A6K133
    Conserved Domains (1) summary
    COG2835
    Location:50 → 105
    YcaR; Uncharacterized conserved protein YbaR, Trm112 family [Function unknown]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    88832008..88835643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U1Z8.1 GenPept UniProtKB/Swiss-Prot:Q5U1Z8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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