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Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory [ Rattus norvegicus (Norway rat) ]

Gene ID: 502017, updated on 10-Jul-2024

Summary

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Official Symbol
Dpm3provided by RGD
Official Full Name
dolichyl-phosphate mannosyltransferase subunit 3, regulatoryprovided by RGD
Primary source
RGD:1561807
See related
EnsemblRapid:ENSRNOG00000086733 AllianceGenome:RGD:1561807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561807
Summary
Predicted to enable enzyme activator activity. Predicted to be involved in GPI anchor biosynthetic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and muscular dystrophy-dystroglycanopathy. Orthologous to human DPM3 (dolichyl-phosphate mannosyltransferase subunit 3, regulatory). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 203.0), Kidney (RPKM 187.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dpm3 in Genome Data Viewer
Location:
2q34
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176974290..176974805)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174676532..174677047)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188583664..188584179)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mucin 1, cell surface associated Neighboring gene tripartite motif-containing 46 Neighboring gene keratinocyte associated protein 2 Neighboring gene solute carrier family 50 member 1 Neighboring gene ephrin A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. Maeda Y, et al. EMBO J, 2000 Jun 1. PMID 10835346, Free PMC Article
  2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of dolichol-phosphate-mannose synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dolichol-phosphate-mannose synthase complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dolichol-phosphate mannosyltransferase subunit 3
Names
dolichyl-phosphate mannosyltransferase polypeptide 3
NP_001102801.1
XP_038958890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109331.2 → NP_001102801.1  dolichol-phosphate mannosyltransferase subunit 3

    See identical proteins and their annotated locations for NP_001102801.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6J6D9, D3ZIJ5
    Related
    ENSRNOP00000099299.1, ENSRNOT00000158006.1
    Conserved Domains (1) summary
    pfam08285
    Location:1 → 90
    DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    176974290..176974805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102962.2 → XP_038958890.1  dolichol-phosphate mannosyltransferase subunit 3 isoform X1

    UniProtKB/TrEMBL
    A6J6D9, D3ZIJ5
    Conserved Domains (1) summary
    pfam08285
    Location:1 → 90
    DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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