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Acaa1b acetyl-Coenzyme A acyltransferase 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 501072, updated on 2-Nov-2024

Summary

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Official Symbol
Acaa1bprovided by RGD
Official Full Name
acetyl-Coenzyme A acyltransferase 1Bprovided by RGD
Primary source
RGD:1562373
See related
EnsemblRapid:ENSRNOG00000067803 AllianceGenome:RGD:1562373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562373
Summary
Predicted to enable acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation and phenylacetate catabolic process. Located in peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 227.8), Liver (RPKM 177.5) and 4 other tissues See more
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Genomic context

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See Acaa1b in Genome Data Viewer
Location:
8q32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127750771..127759589, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (118872996..118881852, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127836235..127845296, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene villin-like Neighboring gene phospholipase C, delta 1 Neighboring gene uncharacterized LOC102548352 Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene solute carrier family 22, member 14 Neighboring gene solute carrier family 22 member 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase. Hijikata M, et al. J Biol Chem, 1987 Jun 15. PMID 3036803
  2. Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two closely related but differentially regulated genes. Hijikata M, et al. J Biol Chem, 1990 Mar 15. PMID 2307679
  3. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. Swinkels BW, et al. EMBO J, 1991 Nov. PMID 1680677, Free PMC Article
  4. Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins. Ghys K, et al. Biochem J, 2002 Jul 1. PMID 11931631, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA C-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA C-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylacetate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-ketoacyl-CoA thiolase B, peroxisomal
Names
acetyl-CoA acyltransferase B
beta-ketothiolase B
peroxisomal 3-ketoacyl-CoA thiolase B
peroxisomal 3-oxoacyl-CoA thiolase B
NP_001035108.2
XP_038937924.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040019.3 → NP_001035108.2  3-ketoacyl-CoA thiolase B, peroxisomal precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P07871, Q4G049
    UniProtKB/TrEMBL
    A0A8I6AEX9, A6I3V2
    Related
    ENSRNOP00000086036.1, ENSRNOT00000106186.2
    Conserved Domains (1) summary
    PLN02287
    Location:1 → 420
    PLN02287; 3-ketoacyl-CoA thiolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    127750771..127759589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081996.2 → XP_038937924.1  3-ketoacyl-CoA thiolase B, peroxisomal isoform X1

    Conserved Domains (1) summary
    PLN02287
    Location:1 → 333
    PLN02287; 3-ketoacyl-CoA thiolase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07871.2 GenPept UniProtKB/Swiss-Prot:P07871

Gene LinkOut

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