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Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497932, updated on 10-Oct-2024

Summary

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Official Symbol
Pik3r6provided by RGD
Official Full Name
phosphoinositide-3-kinase, regulatory subunit 6provided by RGD
Primary source
RGD:1560850
See related
EnsemblRapid:ENSRNOG00000003992 AllianceGenome:RGD:1560850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560850
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to contribute to phosphatidylinositol-4,5-bisphosphate 3-kinase activity. Predicted to be involved in several processes, including positive regulation of MAP kinase activity; positive regulation of angiogenesis; and regulation of natural killer cell mediated cytotoxicity. Predicted to be located in membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class IB. Orthologous to human PIK3R6 (phosphoinositide-3-kinase regulatory subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 31.8), Lung (RPKM 24.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pik3r6 in Genome Data Viewer
Location:
10q24
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (53702821..53754113)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53203930..53255229)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55085269..55135069)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphoinositide-3-kinase, regulatory subunit 5 like 1 Neighboring gene phosphoinositide-3-kinase, regulatory subunit 5 Neighboring gene transfer RNA threonine (anticodon UGU) 2 Neighboring gene major facilitator superfamily domain containing 6-like Neighboring gene uncharacterized LOC120095125

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Signal amplification between Gbetagamma release and PI3Kgamma-mediated PI(3,4,5)P3 formation monitored by a fluorescent Gbetagamma biosensor protein and repetitive two component total internal reflection/fluorescence redistribution after photobleaching analysis. Tannert A, et al. Biochemistry, 2008 Oct 28. PMID 18831540
  2. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Jiang K, et al. Nat Immunol, 2000 Nov. PMID 11062502
  3. BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling. Liu M, et al. Hypertension, 2022 Dec. PMID 36252138
  4. Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio. Rodríguez-Borlado L, et al. J Immunol, 2003 May 1. PMID 12707323
  5. Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Kurig B, et al. Proc Natl Acad Sci U S A, 2009 Dec 1. PMID 19906996, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling.
    Title: BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class IA ISO
Inferred from Sequence Orthology
more info
  
part_of phosphatidylinositol 3-kinase complex, class IB ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphoinositide 3-kinase regulatory subunit 6
Names
p87 phosphoinositide 3-kinase gamma adapter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081444.2 → NP_001074913.2  phosphoinositide 3-kinase regulatory subunit 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    F1LNJ8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    53702821..53754113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086581.2 → XP_038942509.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X5

    Conserved Domains (1) summary
    pfam10486
    Location:104 → 363
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  2. XM_039086580.2 → XP_038942508.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X5

    Conserved Domains (1) summary
    pfam10486
    Location:104 → 363
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  3. XM_039086575.1 → XP_038942503.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G942, A2TJT9
    Related
    ENSRNOP00000083483.2, ENSRNOT00000117827.2
    Conserved Domains (1) summary
    pfam10486
    Location:104 → 823
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  4. XM_039086574.1 → XP_038942502.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G942, A2TJT9
    Conserved Domains (1) summary
    pfam10486
    Location:104 → 823
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  5. XM_039086576.2 → XP_038942504.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G942, A2TJT9
    Related
    ENSRNOP00000100735.1, ENSRNOT00000162807.1
    Conserved Domains (1) summary
    pfam10486
    Location:104 → 800
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  6. XM_039086578.2 → XP_038942506.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I6G942
    Related
    ENSRNOP00000005405.6, ENSRNOT00000005405.9
    Conserved Domains (1) summary
    pfam10486
    Location:38 → 716
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  7. XM_039086579.1 → XP_038942507.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X4

    UniProtKB/TrEMBL
    A0A8I6G942, A2TJT9, F1LNJ8
    Conserved Domains (1) summary
    pfam10486
    Location:34 → 753
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  8. XM_039086577.2 → XP_038942505.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I6G942
    Conserved Domains (1) summary
    pfam10486
    Location:38 → 716
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RNA

  1. XR_005489908.2 RNA Sequence

  2. XR_005489906.2 RNA Sequence

  3. XR_005489905.2 RNA Sequence

  4. XR_005489907.2 RNA Sequence

    Related
    ENSRNOT00000169773.1
Nucleotide Protein Strain
Heading Accession and Version

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