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Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497931, updated on 10-Oct-2024

Summary

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Official Symbol
Pik3r5provided by RGD
Official Full Name
phosphoinositide-3-kinase, regulatory subunit 5provided by RGD
Primary source
RGD:1563261
See related
EnsemblRapid:ENSRNOG00000023428 AllianceGenome:RGD:1563261
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563261
Summary
Enables 1-phosphatidylinositol-3-kinase regulator activity. Involved in regulation of phosphatidylinositol 3-kinase activity. Part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 55.1), Thymus (RPKM 53.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pik3r5 in Genome Data Viewer
Location:
10q24
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (53631469..53699550)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53132585..53200663)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55013686..55078986)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene syntaxin 8 Neighboring gene uncharacterized LOC134480811 Neighboring gene netrin 1 Neighboring gene phosphoinositide-3-kinase, regulatory subunit 5 like 1 Neighboring gene transfer RNA threonine (anticodon UGU) 2 Neighboring gene phosphoinositide-3-kinase, regulatory subunit 6 Neighboring gene major facilitator superfamily domain containing 6-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation. Kondo Y, et al. Proc Natl Acad Sci U S A, 2004 May 11. PMID 15123805, Free PMC Article
  2. Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma. Voigt P, et al. J Biol Chem, 2005 Feb 11. PMID 15611065
  3. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. Kaplan-Albuquerque N, et al. J Biol Chem, 2003 Oct 10. PMID 12882977
  4. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. Brock C, et al. J Cell Biol, 2003 Jan 6. PMID 12507995, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-3-kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables G-protein beta/gamma-subunit complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA ISO
Inferred from Sequence Orthology
more info
  
part_of phosphatidylinositol 3-kinase complex, class IB IEA
Inferred from Electronic Annotation
more info
  
part_of phosphatidylinositol 3-kinase complex, class IB ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoinositide 3-kinase regulatory subunit 5
Names
phosphoinositide-3-kinase, regulatory subunit 5, p101

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191923.1 → NP_001178852.1  phosphoinositide 3-kinase regulatory subunit 5

    See identical proteins and their annotated locations for NP_001178852.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HFK4, D4A4I3
    Conserved Domains (1) summary
    pfam10486
    Location:6 → 872
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    53631469..53699550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246770.5 → XP_006246832.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

    See identical proteins and their annotated locations for XP_006246832.1

    UniProtKB/TrEMBL
    A6HFK4, D4A4I3
    Related
    ENSRNOP00000030578.3, ENSRNOT00000032785.7
    Conserved Domains (1) summary
    pfam10486
    Location:6 → 872
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  2. XM_017597454.3 → XP_017452943.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X2

    UniProtKB/TrEMBL
    A6HFK4

  3. XM_039086573.2 → XP_038942501.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

    UniProtKB/TrEMBL
    A6HFK4, D4A4I3
    Conserved Domains (1) summary
    pfam10486
    Location:6 → 872
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  4. XM_063269619.1 → XP_063125689.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

    UniProtKB/TrEMBL
    D4A4I3

  5. XM_063269618.1 → XP_063125688.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

    UniProtKB/TrEMBL
    D4A4I3
Nucleotide Protein Strain
Heading Accession and Version

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