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UROD uroporphyrinogen decarboxylase [ Ovis aries (sheep) ]

Gene ID: 497117, updated on 5-Mar-2024

Summary

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Gene symbol
UROD
Gene description
uroporphyrinogen decarboxylase
See related
EnsemblRapid:ENSOARG00020003627
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See UROD in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 1 NC_056054.1 (19663992..19667360)

Chromosome 1 - NC_056054.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B subunit gamma Neighboring gene glycine cleavage system H protein, mitochondrial-like Neighboring gene HECT domain E3 ubiquitin protein ligase 3 Neighboring gene zinc finger SWIM-type containing 5 Neighboring gene large ribosomal subunit protein uL6-like Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056054.1 Chromosome 1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a mutation in the ovine uroporphyrinogen decarboxylase (UROD) gene associated with a type of porphyria. Nezamzadeh R, et al. Anim Genet, 2005 Aug. PMID 16026339
  2. Assignment of the ovine uroporphyrinogen decarboxylase (UROD) gene to chromosome 1p34 --> p36 by fluorescence in situ hybridization. Nezamzadeh R, et al. Cytogenet Genome Res, 2004. PMID 15222308

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mutation in the ovine uroporphyrinogen decarboxylase (UROD) gene, which leads to an amino acid substitution at Leu 131 Pro, is associated with a type of porphyria.
    Title: Identification of a mutation in the ovine uroporphyrinogen decarboxylase (UROD) gene associated with a type of porphyria.
  2. uroporphyrinogen decarboxylase gene mapped to ovine chromosome 1
    Title: Assignment of the ovine uroporphyrinogen decarboxylase (UROD) gene to chromosome 1p34 --> p36 by fluorescence in situ hybridization.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables uroporphyrinogen decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
uroporphyrinogen decarboxylase
Names
UPD
URO-D
NP_001012341.1
XP_042103588.1
XP_042103637.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012341.1 → NP_001012341.1  uroporphyrinogen decarboxylase

    See identical proteins and their annotated locations for NP_001012341.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ295031
    UniProtKB/Swiss-Prot
    Q8HY31
    UniProtKB/TrEMBL
    A0A836D7U0
    Related
    ENSOARP00020004689.1, ENSOART00020005698.2
    Conserved Domains (1) summary
    cd00717
    Location:20 → 359
    URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056054.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    19663992..19667360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042247654.1 → XP_042103588.1  uroporphyrinogen decarboxylase isoform X1

    Related
    ENSOARP00020048453.1, ENSOART00020077355.1
    Conserved Domains (1) summary
    cd00717
    Location:30 → 369
    URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...

  2. XM_042247703.1 → XP_042103637.1  uroporphyrinogen decarboxylase isoform X2

    Conserved Domains (1) summary
    cd00717
    Location:30 → 348
    URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8HY31.1 GenPept UniProtKB/Swiss-Prot:Q8HY31

Gene LinkOut

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Research Materials