NCL nucleolin [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: NCL
Gene description: nucleolin
See related: BGD:BT17150; Ensembl:ENSBTAG00000016174
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (119226976..119236929, complement)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that si-RNA induced down-regulation of FUT1 and FUT2 reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface.
Title: RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation.

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General gene information

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Markers

BMON123 (e-PCR)
- UniSTS:251711

NCL (e-PCR)
- UniSTS:503929

Ncl (e-PCR), detects polymorphism
- UniSTS:479178

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables mRNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nucleolin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206660.1 → NP_001193589.1 nucleolin

See identical proteins and their annotated locations for NP_001193589.1

Status: VALIDATED

Source sequence(s)

DV807609, DV910666, EH209294, EV621481, EV700525

UniProtKB/TrEMBL

E1B8K6

Related

ENSBTAP00000021529.5, ENSBTAT00000021529.6

Conserved Domains (5) summary

COG0724
Location:389 → 638

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12403
Location:317 → 391

RRM1_NCL; RNA recognition motif 1 in vertebrate nucleolin

cd12404
Location:400 → 475

RRM2_NCL; RNA recognition motif 2 in vertebrate nucleolin

cd12405
Location:495 → 567

RRM3_NCL; RNA recognition motif 3 in vertebrate nucleolin

cd12406
Location:582 → 659

RRM4_NCL; RNA recognition motif 4 in vertebrate nucleolin