wdr5 WD repeat domain 5 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: wdr5provided by Xenbase
Official Full Name: WD repeat domain 5provided by Xenbase
Primary source: Xenbase:XB-GENE-493883
See related: Ensembl:ENSXETG00000019588
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: swd3; big-3; xwdr5; wdr5-a; wdr5-b
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 8

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (8189535..8202364, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	Unplaced Scaffold	NW_016683374.1 (486721..499384)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wdr5 depletion leads to left right patterning defects in Xenopus via its role in ciliogenesis.
Title: WDR5 regulates left-right patterning via chromatin-dependent and -independent functions.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Set1C/COMPASS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: WD repeat-containing protein 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011411.2 → NP_001011411.1 WD repeat-containing protein 5

See identical proteins and their annotated locations for NP_001011411.1

Status: PROVISIONAL

Source sequence(s)

CR761006

UniProtKB/Swiss-Prot

Q5M786

UniProtKB/TrEMBL

A0A1B8YA81, A0A6I8T0Y3

Related

ENSXETP00000108436.1, ENSXETT00000116442.1

Conserved Domains (2) summary

cd00200
Location:37 → 331

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:48 → 85

7WD40; WD40 repeat [structural motif]