acta2 actin, alpha 2, smooth muscle, aorta [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: acta2provided by Xenbase
Official Full Name: actin, alpha 2, smooth muscle, aortaprovided by Xenbase
Primary source: Xenbase:XB-GENE-493937
See related: Ensembl:ENSXETG00000009279 AllianceGenome:Xenbase:XB-GENE-493937
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: sma; ASMA; aat6; a-sma; actc1; actsa; mymy5; SMactin; sm-actin; alpha-actin
Summary: Predicted to enable ATP binding activity and hydrolase activity. Predicted to be involved in alternative mRNA splicing, via spliceosome; mRNA splice site recognition; and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within mesenchyme migration and positive regulation of gene expression. Predicted to be located in several cellular components, including cell body; filopodium; and lamellipodium. Human ortholog(s) of this gene implicated in Moyamoya disease; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Orthologous to several human genes including ACTA2 (actin alpha 2, smooth muscle). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	7	NC_030683.2 (12721043..12728705)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	7	NC_030683.1 (4480360..4487476)

Chromosome 7 - NC_030683.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

Acta1 (e-PCR), detects polymorphism
- UniSTS:141013

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splice site recognition	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mesenchyme migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin, aortic smooth muscle

Names: SM actin; actin alpha cardiac 1; alpha smooth muscle actin; alpha-SM-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.