hes1 hes family bHLH transcription factor 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: hes1provided by Xenbase
Official Full Name: hes family bHLH transcription factor 1provided by Xenbase
Primary source: Xenbase:XB-GENE-487995
See related: Ensembl:ENSXETG00000016852 AllianceGenome:Xenbase:XB-GENE-487995
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: hhl; hry; hes-1; hairy1; hes1-a; hes1-b; Xhairy1
Summary: Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; bHLH transcription factor binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including Notch signaling pathway; negative regulation of neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of muscle organ development and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	5	NC_030681.2 (106987449..106989866, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	5	NC_030681.1 (96943066..96945483)

Chromosome 5 - NC_030681.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables bHLH transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of muscle organ development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transcription factor HES-1

Names: Protein hairy-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011194.1 → NP_001011194.1 transcription factor HES-1

See identical proteins and their annotated locations for NP_001011194.1

Status: PROVISIONAL

Source sequence(s)

BC087608

UniProtKB/Swiss-Prot

Q5PPM5

Related

ENSXETP00000036731.3, ENSXETT00000036731.5

Conserved Domains (2) summary

pfam07527
Location:110 → 148

Hairy_orange; Hairy Orange

cd11459
Location:33 → 95

bHLH-O_HES1_4; basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split HES-1, HES-4 and similar proteins