adamts1.L ADAM metallopeptidase with thrombospondin type 1 motif 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: adamts1.L
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 1 L homeolog
Primary source: Xenbase:XB-GENE-492604
Locus tag: XELAEV_18011531mg
See related: EnsemblRapid:ENSXLAG00005024660 AllianceGenome:Xenbase:XB-GENE-492604
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: adamts1; xadamts1
Summary: Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Predicted to act upstream of or within extracellular matrix organization and proteolysis. Predicted to be located in extracellular matrix and extracellular region. Is expressed in anatomical system; pharyngeal arch; and primary germ layer. Orthologous to human ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 2L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (17507994..17516993)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (17309143..17318142)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAMTS1 negatively modulates FGF signaling in the Xenopus embryo.
Title: Xenopus ADAMTS1 negatively modulates FGF signaling independent of its metalloprotease activity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADAM metallopeptidase with thrombospondin type 1 motif 1 L homeolog

Names: ADAM metallopeptidase with thrombospondin type 1 motif, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001095158.1 → NP_001088627.1 ADAM metallopeptidase with thrombospondin type 1 motif 1 L homeolog precursor

See identical proteins and their annotated locations for NP_001088627.1

Status: PROVISIONAL

Source sequence(s)

BC086266

UniProtKB/TrEMBL

A0A974HXJ5, Q5U261

Related

ENSXLAP00005073034.1, ENSXLAT00005074599.1

Conserved Domains (6) summary

smart00209
Location:520 → 564

TSP1; Thrombospondin type 1 repeats

cd04273
Location:208 → 414

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:208 → 417

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:43 → 144

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:675 → 792

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:427 → 497

ADAM_CR; ADAM cysteine-rich