FASLG Fas ligand [Felis catus (domestic cat)] - Gene

Summary

Official Symbol: FASLG
Official Full Name: Fas ligand
Primary source: VGNC:VGNC:107871
See related: EnsemblRapid:ENSFCTG00005004734
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Felis catus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as: FASL; TNFSF6
Orthologs: human mouse all
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Genomic context

Location:: chromosome: F1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
105	current	F.catus_Fca126_mat1.0 (GCF_018350175.1)	F1	NC_058384.1 (14760878..14768459)
104	previous assembly	Felis_catus_9.0 (GCF_000181335.3)	F1	NC_018739.3 (16866013..16873600)

Chromosome F1 - NC_058384.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The whole genomes of two affected kittens were sequenced and compared to 82 existing cat genomes. Both BSH kittens had homozygous insertions of an adenine within exon 3 of the FAS-ligand gene. The resultant frameshift and premature stop codon were predicted to result in a severely truncated protein that is unlikely to be able to activate FAS
Title: A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 6

Names: Fas ligand (TNF superfamily, member 6); fas antigen ligand; tumor necrosis factor (ligand) superfamily, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009352.1 → NP_001009352.1 tumor necrosis factor ligand superfamily member 6

See identical proteins and their annotated locations for NP_001009352.1

Status: PROVISIONAL

Source sequence(s)

AB009280

UniProtKB/Swiss-Prot

Q861W5

Related

ENSFCTP00005008352.1, ENSFCTT00005012898.1

Conserved Domains (1) summary

cd00184
Location:145 → 278

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...