gdf3 growth differentiation factor 3 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: gdf3provided by Xenbase
Official Full Name: growth differentiation factor 3provided by Xenbase
Primary source: Xenbase:XB-GENE-487309
See related: Ensembl:ENSXETG00000002076 AllianceGenome:Xenbase:XB-GENE-487309
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: der; gdf1; vgr2; vgr-2; derriere
Summary: Predicted to enable cytokine activity; morphogen activity; and protein homodimerization activity. Predicted to act upstream of or within anterior/posterior pattern specification; determination of left/right symmetry; and mesoderm formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in endoderm. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 3; congenital heart disease; isolated microphthalmia 7; multiple types of congenital heart defects 6; and visceral heterotaxy. Orthologous to several human genes including GDF3 (growth differentiation factor 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (112480766..112533355)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (100370070..100372461)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables morphogen activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within determination of left/right symmetry	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mesoderm formation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: derriere protein

Names: derriA re; derriere (tgf-beta family member); gdf-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007904.1 → NP_001007905.1 derriere protein precursor

See identical proteins and their annotated locations for NP_001007905.1

Status: PROVISIONAL

Source sequence(s)

BC080341

UniProtKB/Swiss-Prot

Q28D13, Q66KL4

UniProtKB/TrEMBL

F6Q1X0

Related

ENSXETP00000004454.2, ENSXETT00000004454.4

Conserved Domains (2) summary

smart00204
Location:249 → 350

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:23 → 195

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

112480766..112533355

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031898480.1 → XP_031754340.1 derriere protein isoform X1

UniProtKB/TrEMBL

A0A803JTG3, F6Q1X0

Conserved Domains (2) summary

cd13764
Location:225 → 326

TGF_beta_GDF1_3_like; transforming growth factor beta (TGF-beta) like domain found in embryonic growth/differentiation factor 1 (GDF1), factor 3 (GDF3) and similar proteins

cl02928
Location:2 → 173

TGFb_propeptide; TGF-beta propeptide