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htt huntingtin [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 493287, updated on 4-Nov-2024

Summary

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Official Symbol
httprovided by Xenbase
Official Full Name
huntingtinprovided by Xenbase
Primary source
Xenbase:XB-GENE-1013462
See related
Ensembl:ENSXETG00000014723 AllianceGenome:Xenbase:XB-GENE-1013462
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
hd; it15; huntington
Summary
Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (huntingtin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See htt in Genome Data Viewer
Location:
chromosome: 1
Exon count:
68
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (22735896..22820901)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (16027379..16111778, complement)

Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene egg cortical granule lectin gene 2 Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene uncharacterized LOC105946263 Neighboring gene Myb/SANT-like DNA-binding domain containing 1 Neighboring gene regulator of G-protein signaling 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC79590

Gene Ontology Provided by Xenbase

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
huntingtin
Names
Huntington disease

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    22735896..22820901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031895313.1 → XP_031751173.1  huntingtin isoform X1

    UniProtKB/TrEMBL
    A0A8J1J007
    Conserved Domains (2) summary
    sd00044
    Location:76 → 98
    HEAT; HEAT repeat [structural motif]
    pfam12372
    Location:1495 → 1535
    DUF3652; Huntingtin protein region

  2. XM_031895314.1 → XP_031751174.1  huntingtin isoform X3

    UniProtKB/TrEMBL
    A0A8J1IZY9
    Conserved Domains (2) summary
    sd00044
    Location:76 → 98
    HEAT; HEAT repeat [structural motif]
    pfam12372
    Location:1479 → 1519
    DUF3652; Huntingtin protein region

  3. XM_012955737.3 → XP_012811191.1  huntingtin isoform X2

    UniProtKB/TrEMBL
    A0A6I8PRJ8, A0A6I8RIL2
    Related
    ENSXETP00000060525.3, ENSXETT00000062928.3
    Conserved Domains (2) summary
    sd00044
    Location:76 → 98
    HEAT; HEAT repeat [structural motif]
    pfam12372
    Location:1482 → 1522
    DUF3652; Huntingtin protein region

  4. XM_012955738.3 → XP_012811192.1  huntingtin isoform X4

    UniProtKB/TrEMBL
    A0A6R5A4C7
    Related
    ENSXETP00000032280.4, ENSXETT00000032280.5
    Conserved Domains (2) summary
    sd00044
    Location:76 → 98
    HEAT; HEAT repeat [structural motif]
    pfam12372
    Location:1466 → 1506
    DUF3652; Huntingtin protein region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007903.1: Suppressed sequence

    Description
    NM_001007903.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: HTT (GeneID:3064).
Nucleotide Protein Strain
Heading Accession and Version

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