mfsd2aa MFSD2 lysolipid transporter A, lysophospholipid a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mfsd2aaprovided by ZNC
Official Full Name: MFSD2 lysolipid transporter A, lysophospholipid aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041114-166
See related: Ensembl:ENSDARG00000030630 AllianceGenome:ZFIN:ZDB-GENE-041114-166
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NLS1-A; mfsd2a; zgc:101615
Summary: Predicted to enable fatty acid transmembrane transporter activity and lysophospholipid:sodium symporter activity. Acts upstream of or within lysophospholipid transport and maintenance of blood-brain barrier. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Is expressed in axis; chondrocranium; nervous system; and polster. Used to study microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 15. Orthologous to human MFSD2A (MFSD2 lysolipid transporter A, lysophospholipid). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (35892382..35954703)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (35766570..35828686)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipid:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables symporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate transport	IEA Inferred from Electronic Annotation more info
involved_in establishment of blood-brain barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport across blood-brain barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid transport across blood-brain barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysophospholipid translocation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysophospholipid transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within maintenance of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sodium-dependent lysophosphatidylcholine symporter 1-A

Names: major facilitator superfamily domain containing 2a; major facilitator superfamily domain containing 2aa; major facilitator superfamily domain-containing protein 2A-A; sodium-dependent LPC symporter 1-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007451.1 → NP_001007452.1 sodium-dependent lysophosphatidylcholine symporter 1-A

See identical proteins and their annotated locations for NP_001007452.1

Status: PROVISIONAL

Source sequence(s)

BC085388

UniProtKB/Swiss-Prot

Q5U3U7

Related

ENSDARP00000046114.4, ENSDART00000046115.5

Conserved Domains (2) summary

pfam13347
Location:45 → 500

MFS_2; MFS/sugar transport protein

cl21472
Location:40 → 510

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

35892382..35954703

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005156993.5 → XP_005157050.1 sodium-dependent lysophosphatidylcholine symporter 1-A isoform X1

UniProtKB/TrEMBL

A0A8M2B365

Conserved Domains (2) summary

pfam13347
Location:63 → 518

MFS_2; MFS/sugar transport protein

cl21472
Location:58 → 528

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...