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ctdnep1b CTD nuclear envelope phosphatase 1b [ Danio rerio (zebrafish) ]

Gene ID: 492799, updated on 18-Sep-2024

Summary

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Official Symbol
ctdnep1bprovided by ZNC
Official Full Name
CTD nuclear envelope phosphatase 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-152
See related
Ensembl:ENSDARG00000035781 AllianceGenome:ZFIN:ZDB-GENE-041114-152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ctdnep1l; dullardl; zgc:101656
Summary
Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within head development. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See ctdnep1b in Genome Data Viewer
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (69449858..69467638)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (69211808..69229588)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496240 Neighboring gene ataxin 1-like Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene GABA(A) receptor-associated protein b Neighboring gene spermatogenesis associated 6-like Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes. Carvalho CM, et al. Am J Hum Genet, 2014 Nov 6. PMID 25439725, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within head development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within head development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear envelope organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Nem1-Spo7 phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CTD nuclear envelope phosphatase 1B
Names
dullard homolog, like
dullard-like protein
serine/threonine-protein phosphatase dullard-B
NP_001007441.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007440.2 → NP_001007441.2  CTD nuclear envelope phosphatase 1B

    Status: VALIDATED

    Source sequence(s)
    CU693476
    UniProtKB/Swiss-Prot
    Q5U3T3
    UniProtKB/TrEMBL
    A0A8M1N3E1, F1Q7Z2
    Related
    ENSDARP00000103636.2, ENSDART00000109644.3
    Conserved Domains (1) summary
    TIGR02251
    Location:65 → 233
    HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    69449858..69467638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U3T3.1 GenPept UniProtKB/Swiss-Prot:Q5U3T3

Gene LinkOut

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