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snrpa1 small nuclear ribonucleoprotein polypeptide A' [ Danio rerio (zebrafish) ]

Gene ID: 492511, updated on 2-Nov-2024

Summary

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Official Symbol
snrpa1provided by ZNC
Official Full Name
small nuclear ribonucleoprotein polypeptide A'provided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-82
See related
Ensembl:ENSDARG00000024651 AllianceGenome:ZFIN:ZDB-GENE-041114-82
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7142962; zgc:101832
Summary
Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be part of U2 snRNP. Is expressed in female organism. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See snrpa1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (9290950..9305586)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (9045444..9060099)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496146 Neighboring gene proprotein convertase subtilisin/kexin type 6 Neighboring gene selenoprotein S Neighboring gene chondroitin sulfate synthase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. CRISPR Guide RNA Validation In Vitro. Grainger S, et al. Zebrafish, 2017 Aug. PMID 27829120, Free PMC Article
  2. Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes. Cañestro C, et al. PLoS Genet, 2009 May. PMID 19478994, Free PMC Article
  3. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U2 small nuclear ribonucleoprotein A'

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007383.2 → NP_001007384.2  U2 small nuclear ribonucleoprotein A'

    Status: VALIDATED

    Source sequence(s)
    CU856378, EH529176, EH548169
    UniProtKB/TrEMBL
    A0A8M1N398, F1R300
    Related
    ENSDARP00000107467.2, ENSDART00000128530.4
    Conserved Domains (4) summary
    smart00446
    Location:128 → 146
    LRRcap; occurring C-terminal to leucine-rich repeats
    pfam14580
    Location:1 → 175
    LRR_9; Leucine-rich repeat
    sd00031
    Location:46 → 65
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:64 → 108
    LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    9290950..9305586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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