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ADAMTSL2 ADAMTS like 2 [ Canis lupus familiaris (dog) ]

Gene ID: 491276, updated on 17-Aug-2024

Summary

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Official Symbol
ADAMTSL2provided by VGNC
Official Full Name
ADAMTS like 2provided by VGNC
Primary source
VGNC:VGNC:37607
See related
Ensembl:ENSCAFG00845010741
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ADAMTSL2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (50799767..50833236)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (49206839..49239889)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (49981616..50014897)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (49561488..49594623)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (49903420..49936530)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 6 Neighboring gene myomaker, myoblast fusion factor Neighboring gene uncharacterized LOC119876663 Neighboring gene uncharacterized LOC119873347 Neighboring gene family with sequence similarity 163 member B Neighboring gene dopamine beta-hydroxylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An ADAMTSL2 founder mutation causes Musladin-Lueke Syndrome, a heritable disorder of beagle dogs, featuring stiff skin and joint contractures. Bader HL, et al. PLoS One, 2010 Sep 17. PMID 20862248, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation in exon 7 of ADAMTSL2 is associated with Musladin-Lueke Syndrome.
    Title: An ADAMTSL2 founder mutation causes Musladin-Lueke Syndrome, a heritable disorder of beagle dogs, featuring stiff skin and joint contractures.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ADAMTS-like protein 2; LOW QUALITY PROTEIN: ADAMTS-like protein 2
Names
ADAMTS-like 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    50799767..50833236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678066.1 → XP_038533994.1  ADAMTS-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LWX0, A0A8C0RVE9, A0A8I3NS78
    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:920 → 951
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:802 → 858
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_038678065.1 → XP_038533993.1  ADAMTS-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LWX0, A0A8C0RVE9, A0A8I3NS78
    Related
    ENSCAFP00845014797.1, ENSCAFT00845018936.1
    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:920 → 951
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:802 → 858
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_038678067.1 → XP_038533995.1  ADAMTS-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RVE9
    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:886 → 917
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:768 → 824
    TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    49561488..49594623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038486990.1 → XP_038342918.1  LOW QUALITY PROTEIN: ADAMTS-like protein 2 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    49903420..49936530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038612771.1 → XP_038468699.1  ADAMTS-like protein 2 isoform X1

    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:920 → 951
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:802 → 858
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_038612770.1 → XP_038468698.1  ADAMTS-like protein 2 isoform X1

    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:920 → 951
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:802 → 858
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_038612772.1 → XP_038468700.1  ADAMTS-like protein 2 isoform X2

    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:886 → 917
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:768 → 824
    TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    49981616..50014897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038548836.1 → XP_038404764.1  ADAMTS-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LWX0, A0A8C0RVE9, A0A8I3NS78
    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:920 → 951
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:802 → 858
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_038548835.1 → XP_038404763.1  ADAMTS-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LWX0, A0A8C0RVE9, A0A8I3NS78
    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:920 → 951
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:802 → 858
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_038548837.1 → XP_038404765.1  ADAMTS-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RVE9
    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:886 → 917
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:768 → 824
    TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    49206839..49239889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014116955.3 → XP_013972430.1  ADAMTS-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RVE9, A0A8P0NL03
    Conserved Domains (3) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:920 → 951
    PLAC; PLAC (protease and lacunin) domain

  2. XM_003639308.5 → XP_003639356.1  ADAMTS-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RVE9, A0A8P0NL03
    Conserved Domains (3) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:920 → 951
    PLAC; PLAC (protease and lacunin) domain

  3. XM_005625150.4 → XP_005625207.1  ADAMTS-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RVE9
    Conserved Domains (3) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:886 → 917
    PLAC; PLAC (protease and lacunin) domain
Nucleotide Protein
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