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SPTB spectrin beta, erythrocytic [ Canis lupus familiaris (dog) ]

Gene ID: 490734, updated on 17-Aug-2024

Summary

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Official Symbol
SPTBprovided by VGNC
Official Full Name
spectrin beta, erythrocyticprovided by VGNC
Primary source
VGNC:VGNC:46774
See related
Ensembl:ENSCAFG00845002451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SPTB in Genome Data Viewer
Location:
chromosome: 8
Exon count:
38
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (39377314..39523986, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (38861964..38913675, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (39445769..39497441, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (39013953..39065557, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (39086903..39138647, complement)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119872869 Neighboring gene pleckstrin homology and RhoGEF domain containing G3 Neighboring gene uncharacterized LOC106559168 Neighboring gene churchill domain containing 1 Neighboring gene glutathione peroxidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Canine elliptocytosis due to a mutant beta-spectrin. Di Terlizzi R, et al. Vet Clin Pathol, 2009 Mar. PMID 19228356
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of spectrin IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
spectrin beta chain, erythrocytic
Names
spectrin, beta, erythrocytic (includes spherocytosis, clinical type I)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001220481.2 → NP_001207410.2  spectrin beta chain, erythrocytic

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000053
    UniProtKB/TrEMBL
    A0A8I3RQQ5, A0A8P0TLN4
    Conserved Domains (5) summary
    smart00150
    Location:1171 → 1265
    SPEC; Spectrin repeats
    cd00176
    Location:530 → 742
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:422 → 525
    Spectrin; Spectrin repeat
    cd21317
    Location:25 → 156
    CH_SPTBN2_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins
    cd21319
    Location:170 → 281
    CH_SPTB_rpt2; second calponin homology (CH) domain found in spectrin beta chain, erythrocytic (SPTB) and similar proteins

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    39377314..39523986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038672919.1 → XP_038528847.1  spectrin beta chain, erythrocytic isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSR5, A0A8I3RS77
    Conserved Domains (6) summary
    smart00150
    Location:1171 → 1265
    SPEC; Spectrin repeats
    cd00176
    Location:530 → 742
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:2179 → 2284
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00435
    Location:422 → 525
    Spectrin; Spectrin repeat
    cd21317
    Location:25 → 156
    CH_SPTBN2_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins
    cd21319
    Location:170 → 281
    CH_SPTB_rpt2; second calponin homology (CH) domain found in spectrin beta chain, erythrocytic (SPTB) and similar proteins

  2. XM_038672918.1 → XP_038528846.1  spectrin beta chain, erythrocytic isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSR5, A0A8I3RS77
    Related
    ENSCAFP00845003462.1, ENSCAFT00845004336.1
    Conserved Domains (6) summary
    smart00150
    Location:1171 → 1265
    SPEC; Spectrin repeats
    cd00176
    Location:530 → 742
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:2179 → 2284
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00435
    Location:422 → 525
    Spectrin; Spectrin repeat
    cd21317
    Location:25 → 156
    CH_SPTBN2_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins
    cd21319
    Location:170 → 281
    CH_SPTB_rpt2; second calponin homology (CH) domain found in spectrin beta chain, erythrocytic (SPTB) and similar proteins

  3. XM_038672920.1 → XP_038528848.1  spectrin beta chain, erythrocytic isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSR5, A0A8I3RS77
    Conserved Domains (6) summary
    smart00150
    Location:1171 → 1265
    SPEC; Spectrin repeats
    cd00176
    Location:530 → 742
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd10571
    Location:2179 → 2284
    PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
    pfam00435
    Location:422 → 525
    Spectrin; Spectrin repeat
    cd21317
    Location:25 → 156
    CH_SPTBN2_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins
    cd21319
    Location:170 → 281
    CH_SPTB_rpt2; second calponin homology (CH) domain found in spectrin beta chain, erythrocytic (SPTB) and similar proteins

  4. XM_038672921.1 → XP_038528849.1  spectrin beta chain, erythrocytic isoform X2

    UniProtKB/TrEMBL
    A0A8I3RQQ5, A0A8P0TLN4
    Related
    ENSCAFP00845003475.1, ENSCAFT00845004351.1
    Conserved Domains (5) summary
    smart00150
    Location:1171 → 1265
    SPEC; Spectrin repeats
    cd00176
    Location:530 → 742
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:422 → 525
    Spectrin; Spectrin repeat
    cd21317
    Location:25 → 156
    CH_SPTBN2_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins
    cd21319
    Location:170 → 281
    CH_SPTB_rpt2; second calponin homology (CH) domain found in spectrin beta chain, erythrocytic (SPTB) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    39013953..39065557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    39086903..39138647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    39445769..39497441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    38861964..38913675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
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