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HSF4 heat shock transcription factor 4 [ Canis lupus familiaris (dog) ]

Gene ID: 489766, updated on 22-Jan-2024

Summary

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Gene symbol
HSF4
Gene description
heat shock transcription factor 4
See related
Ensembl:ENSCAFG00845009966 Ensembl:ENSCAFG00845010066
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
NOL3
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Genomic context

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See HSF4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (82626129..82635528, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (82185252..82189780, complement) , (82180441..82184478, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (82781845..82786373, complement) , (82777034..82781071, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (82457029..82461556, complement) , (82452219..82456256, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (82142571..82147095, complement) , (82137760..82141798, complement)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111096057 Neighboring gene exocyst complex component 3 like 1 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene TNFRSF1A associated via death domain Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene phagosome assembly factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation in HSF4 is associated with hereditary cataract in the Australian Shepherd. Mellersh CS, et al. Vet Ophthalmol, 2009 Nov-Dec. PMID 19883468
  2. Known insertion/deletion mutations in exon 9 of heat shock transcription factor 4 are not responsible for juvenile hereditary cataract in Siberian Husky dogs. Gentilini F, et al. Anim Genet, 2008 Oct. PMID 18680491
  3. Evaluation of canine heat shock transcription factor 4 (HSF4) as a candidate gene for primary cataracts in the Dachshund and the Entlebucher Mountain dog. Müller C, et al. Vet Ophthalmol, 2008 Jan-Feb. PMID 18190350
  4. Evaluation of canine heat-shock transcription factor 4 as a candidate for primary cataracts in English Cocker Spaniels and wire-haired Kromfohrlanders. Engelhardt A, et al. J Anim Breed Genet, 2007 Aug. PMID 17651328
  5. Mutation in HSF4 associated with early but not late-onset hereditary cataract in the Boston Terrier. Mellersh CS, et al. J Hered, 2007. PMID 17611257

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of HSF4 is significantly associated with cataracts and a dog carrying the mutation is approximately 17 times more likely to develop binocular cataracts than dogs that are clear of the mutation.
    Title: Mutation in HSF4 is associated with hereditary cataract in the Australian Shepherd.
  2. insertion/deletion mutations in exon 9 of heat shock transcription factor 4 are not responsible for juvenile hereditary cataract in Siberian Husky dogs
    Title: Known insertion/deletion mutations in exon 9 of heat shock transcription factor 4 are not responsible for juvenile hereditary cataract in Siberian Husky dogs.
  3. We found a single nucleotide polymorphism in intron 9 which was neither associated nor linked with the CAT phenotype in the two dog breeds
    Title: Evaluation of canine heat shock transcription factor 4 (HSF4) as a candidate gene for primary cataracts in the Dachshund and the Entlebucher Mountain dog.
  4. HSF4 is not associated with the development of the late-onset form of cataract and the 2 forms of cataract in Boston Terriers are therefore genetically discrete conditions.
    Title: Mutation in HSF4 associated with early but not late-onset hereditary cataract in the Boston Terrier.
  5. Article could not verify that the mutation in exon 9 of canine HSF4 gene is causative for primary cataracts in dog breeds.
    Title: Evaluation of canine heat-shock transcription factor 4 as a candidate for primary cataracts in English Cocker Spaniels and wire-haired Kromfohrlanders.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables caspase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables death effector domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables death receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in inhibition of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
heat shock factor protein 4
Names
HSF 4
HSTF 4
nucleolar protein 3 (apoptosis repressor with CARD domain)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048121.1 → NP_001041586.1  heat shock factor protein 4

    See identical proteins and their annotated locations for NP_001041586.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ487185
    UniProtKB/Swiss-Prot
    Q1HGE6, Q1HGE7, Q1HGE8
    Related
    ENSCAFP00845013908.1, ENSCAFT00845017857.1
    Conserved Domains (2) summary
    smart00415
    Location:16 → 120
    HSF; heat shock factor
    pfam15035
    Location:110 → 175
    Rootletin; Ciliary rootlet component, centrosome cohesion

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    82626129..82635528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664203.1 → XP_038520131.1  heat shock factor protein 4 isoform X3

    Conserved Domains (2) summary
    smart00415
    Location:16 → 120
    HSF; heat shock factor
    cl14633
    Location:433 → 521
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_038664202.1 → XP_038520130.1  heat shock factor protein 4 isoform X2

    Conserved Domains (3) summary
    smart00415
    Location:16 → 120
    HSF; heat shock factor
    pfam06546
    Location:260 → 423
    Vert_HS_TF; Vertebrate heat shock transcription factor
    cl14633
    Location:509 → 597
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_038664204.1 → XP_038520132.1  heat shock factor protein 4 isoform X4

    Conserved Domains (1) summary
    cl14633
    Location:261 → 349
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_038664205.1 → XP_038520133.1  heat shock factor protein 4 isoform X4

    Conserved Domains (1) summary
    cl14633
    Location:261 → 349
    DD; Death Domain Superfamily of protein-protein interaction domains

  5. XM_038664206.1 → XP_038520134.1  heat shock factor protein 4 isoform X5

    Conserved Domains (1) summary
    cl14633
    Location:90 → 178
    DD; Death Domain Superfamily of protein-protein interaction domains

  6. XM_038664207.1 → XP_038520135.1  heat shock factor protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Related
    ENSCAFP00845013639.1, ENSCAFT00845017525.1
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  7. XM_038664209.1 → XP_038520137.1  heat shock factor protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  8. XM_038664210.1 → XP_038520138.1  heat shock factor protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  9. XM_038664208.1 → XP_038520136.1  heat shock factor protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  10. XM_038664211.1 → XP_038520139.1  heat shock factor protein 4 isoform X6

    Conserved Domains (3) summary
    smart00415
    Location:16 → 120
    HSF; heat shock factor
    PHA03247
    Location:203 → 380
    PHA03247; large tegument protein UL36; Provisional
    pfam15035
    Location:110 → 175
    Rootletin; Ciliary rootlet component, centrosome cohesion

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    82452219..82456256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    82457029..82461556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038477473.1 → XP_038333401.1  heat shock factor protein 4 isoform X1

    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_038477475.1 → XP_038333403.1  heat shock factor protein 4 isoform X1

    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_038477476.1 → XP_038333404.1  heat shock factor protein 4 isoform X1

    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_038477474.1 → XP_038333402.1  heat shock factor protein 4 isoform X1

    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    82137760..82141798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    82142571..82147095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038602793.1 → XP_038458721.1  heat shock factor protein 4 isoform X1

    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_038602795.1 → XP_038458723.1  heat shock factor protein 4 isoform X1

    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_038602796.1 → XP_038458724.1  heat shock factor protein 4 isoform X1

    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_038602794.1 → XP_038458722.1  heat shock factor protein 4 isoform X1

    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    82777034..82781071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    82781845..82786373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038538688.1 → XP_038394616.1  heat shock factor protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_038538690.1 → XP_038394618.1  heat shock factor protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_038538691.1 → XP_038394619.1  heat shock factor protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_038538689.1 → XP_038394617.1  heat shock factor protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    82180441..82184478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    82185252..82189780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_848890.5 → XP_853983.1  heat shock factor protein 4 isoform X1

    See identical proteins and their annotated locations for XP_853983.1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_005620855.4 → XP_005620912.1  heat shock factor protein 4 isoform X1

    See identical proteins and their annotated locations for XP_005620912.1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_014113965.3 → XP_013969440.1  heat shock factor protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_014113964.3 → XP_013969439.1  heat shock factor protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0R352, A0A8C0Z157, A0A8I3NEH9
    Conserved Domains (1) summary
    cl14633
    Location:4 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1HGE8.1 GenPept UniProtKB/Swiss-Prot:Q1HGE8

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