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ATP1B2 ATPase Na+/K+ transporting subunit beta 2 [ Canis lupus familiaris (dog) ]

Gene ID: 489479, updated on 17-Aug-2024

Summary

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Official Symbol
ATP1B2provided by VGNC
Official Full Name
ATPase Na+/K+ transporting subunit beta 2provided by VGNC
Primary source
VGNC:VGNC:38249
See related
Ensembl:ENSCAFG00845024364
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ATP1B2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (32653348..32659884)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (32687510..32694048)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (32756419..32762956)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (32621044..32627582)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (32577297..32583829)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene sex hormone binding globulin Neighboring gene uncharacterized LOC111095878 Neighboring gene tumor protein p53 Neighboring gene WD repeat containing antisense to TP53 Neighboring gene ephrin B3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A SINE Insertion in ATP1B2 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA2). Mauri N, et al. G3 (Bethesda), 2017 Aug 7. PMID 28620085, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATP1B2:c.130_131ins227 the most likely candidate causative variant for a second subtype of Spongy degeneration with cerebellar ataxia in Malinois dogs.
    Title: A SINE Insertion in ATP1B2 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA2).
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of sodium:potassium-exchanging ATPase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium/potassium-transporting ATPase subunit beta-2
XP_038331479.1
XP_038331480.1
XP_038371336.1
XP_038392648.1
XP_038392650.1
XP_038456823.1
XP_038456824.1
XP_038521367.1
XP_038521368.1
XP_546597.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    32653348..32659884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038665440.1 → XP_038521368.1  sodium/potassium-transporting ATPase subunit beta-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PQA5, A0A8I3PRE0, A0A8P0NVR8, A0A8P0SL13
    Related
    ENSCAFP00845033797.1, ENSCAFT00845043112.1
    Conserved Domains (1) summary
    TIGR01107
    Location:2 → 282
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

  2. XM_038665439.1 → XP_038521367.1  sodium/potassium-transporting ATPase subunit beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1M5, A0A8C0NJN6, A0A8I3PQA5, A0A8I3PRQ0, A0A8P0NVR8
    Related
    ENSCAFP00845033855.1, ENSCAFT00845043179.1
    Conserved Domains (1) summary
    TIGR01107
    Location:2 → 289
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    32621044..32627582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038475552.1 → XP_038331480.1  sodium/potassium-transporting ATPase subunit beta-2 isoform X2

    Conserved Domains (1) summary
    TIGR01107
    Location:2 → 282
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

  2. XM_038475551.1 → XP_038331479.1  sodium/potassium-transporting ATPase subunit beta-2 isoform X1

    Conserved Domains (1) summary
    TIGR01107
    Location:2 → 289
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    32577297..32583829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038600896.1 → XP_038456824.1  sodium/potassium-transporting ATPase subunit beta-2 isoform X2

    Conserved Domains (1) summary
    TIGR01107
    Location:2 → 282
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

  2. XM_038600895.1 → XP_038456823.1  sodium/potassium-transporting ATPase subunit beta-2 isoform X1

    Conserved Domains (1) summary
    TIGR01107
    Location:2 → 289
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    32756419..32762956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038536722.1 → XP_038392650.1  sodium/potassium-transporting ATPase subunit beta-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PQA5, A0A8I3PRE0, A0A8P0NVR8, A0A8P0SL13
    Conserved Domains (1) summary
    TIGR01107
    Location:2 → 282
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

  2. XM_038536720.1 → XP_038392648.1  sodium/potassium-transporting ATPase subunit beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1M5, A0A8C0NJN6, A0A8I3PQA5, A0A8I3PRQ0, A0A8P0NVR8
    Conserved Domains (1) summary
    TIGR01107
    Location:2 → 289
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    32687510..32694048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038515408.1 → XP_038371336.1  sodium/potassium-transporting ATPase subunit beta-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PQA5, A0A8I3PRE0, A0A8P0NVR8, A0A8P0SL13
    Conserved Domains (1) summary
    TIGR01107
    Location:2 → 282
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

  2. XM_546597.7 → XP_546597.2  sodium/potassium-transporting ATPase subunit beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1M5, A0A8C0NJN6, A0A8I3PQA5, A0A8I3PRQ0, A0A8P0NVR8
    Conserved Domains (1) summary
    TIGR01107
    Location:2 → 289
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit
Nucleotide Protein
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